Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1990-05-30
1992-10-27
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424450, 436829, 534 14, A61K 4300, A61K 4902, A61K 9127, A61K 9133
Patent
active
051587602
ABSTRACT:
The invention relates to a .sup.99m Tc-labeled liposome encapsulated protein and to a highly efficient method of radiolabeling liposome encapsulated protein. In particular, a .sup.99m Tc carrier is used to label preformed liposome-encapsulated hemoglobin. The liposome-encapsulated .sup.99m Tc labeled hemoglobin is highly stable in vitro and in vivo and is suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of using technetium-.sup.99m labeled liposome encapsulated hemoglobin to label neutrophils. A kit method which could be used for the convenient preparation of .sup.99m Tc-labeled liposome encapsulated hemoglobin for clinical use is also disclosed.
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The United States Government may have a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of Grant No. N 00014-89-K-0077 awarded by the Office of Naval Research.
Klipper Robert W.
Phillips William T.
Rudolph Alan S.
Timmons James H.
Board of Regents , The University of Texas System
Covert John M.
Lovering Richard D.
The United States of America as represented by the Secretary of
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