Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1990-11-05
1992-09-01
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
534 10, 534 14, 424450, 4284022, 435 724, A61K 4300, A61K 4902, A61K 9127
Patent
active
051437139
ABSTRACT:
The invention relates to the efficient preparation of radionuclide labeled liposomes and radionuclide-labeled liposome-encapsulated protein. In particular, a .sup.99m Tc carrier is used to label preformed liposomes or liposome-encapsulated hemoglobin. .sup.99m Tc-labeled liposomes and liposome-encapsulated .sup.99m Tc labeled hemoglobin are highly stable in vitro and in vivo and are suitable for a variety of clinical uses, including biodistribution imaging studies. The invention also relates to a method of labeling neutrophils using .sup.99m technetium-labeled liposomes or liposome-encapsulated hemoglobin. A kit method useful for the convenient preparation of .sup.99m Tc-labeled liposomes or liposome-encapsulated hemoglobin for clinical use is also disclosed.
REFERENCES:
patent: 4335095 (1982-06-01), Kelly
patent: 4452774 (1984-06-01), Jones et al.
patent: 4615876 (1986-10-01), Troutner et al.
patent: 4707544 (1987-11-01), Jones et al.
patent: 4735793 (1988-04-01), Jones et al.
patent: 4789736 (1988-12-01), Canning et al.
patent: 4826961 (1989-04-01), Jones et al.
patent: 4911929 (1990-03-01), Farmer et al.
patent: 4925650 (1988-11-01), Nosco et al.
patent: 4935223 (1990-06-01), Phillips
patent: 4938947 (1990-07-01), Nicolau et al.
patent: 5019369 (1991-05-01), Presant et al.
patent: 5049391 (1991-09-01), Suzuki et al.
Atsushi Takeda et al., "Intensification of Tumor Affinity of .sup.99m TC-Homocysteine by Cooperative Use of SH-containing Compounds", Nucl. Med. Biol., vol. 16, No. 6, pp. 581-585, 1989.
Claire De Labriolle-Vaylet et al., "Morphological and Functional Status of Leukocytes Labelled with .sup.99m Technetium HMPAO", Radiolabelled Cellular Blood Elements, pp. 119-129.
Laurence Guilloteau et al., "Recruitment of .sup.99m -Technetium- or 111-Indium-Labelled Polymorphonuclear Leucocytes in Experimentally Induced Polygranulomas in Lambs", J. of Leukocyte Bio., vol. 48, pp. 343-352, (1990).
Dialog Search Report.
Karl J. Hwang, "Liposome Pharmacokinetics," In: Liposomes from Biophysics to Therapeutics (M. J. Ostro, Ed.), pp. 109-156 (Marcel Dekker, Inc.) New York 1987.
Caride and Sostman, "Methodological Considerations for the Use of Liposomes in Diagnostic Imaging," Liposome Technology, vol. II:107-124 (1984).
Barratt et al., "The Labeling of Liposomal Membranes with Radioactive Technetium," Liposome Technology vol. II:93-106 (1984).
Beaumier and Hwang, "An Efficient Method for Loading Indium-111 into Liposomes Using Acetylacetone," J. of Nucl. Med. 23(9):810-815.
Caride, Vincente J. "Technical and Biological Considerations on the Use of Radio-labeled Liposomes for Diagnostic Imaging," Nucl. Med. Biol. 17(1):35-39 (1990).
Turner et al., "In-111-labeled liposomes: Dosimetry and Tumor Depiction," Radiology 166:761-765 (1988).
Proffitt et al., "Tumor-Imaging Potential of Liposomes Loaded with In-111-NTA: Biodistribution in Mice," J. of Nucl. Med. 24(1):45-51 (1983).
Hnatowich et al., "Labeling of Preformed Liposomes with Ga-67 and Tc-99m by Chelation," J. of Nucl. Med. 22(9):810-814 (1981).
Love et al., "Effect of liposome surface charge on the stability of technetium (.sup.99m Tc) radiolabelled liposomes," J. Microencapsulation 6(1):105-113 (1989).
O'Sullivan et al., "Inflammatory joint disease: a comparison of liposome scanning, bone scanning, and radiography," Annals of the Rheumatic Diseases 47:485-491 (1988).
Williams et al., "Synovial accumulation of technetium labelled liposomes in rheumatoid arthritis," Annals of the Rheumatic Diseases 46:314-318 (1987).
Morgan et al., "Localisation of experimental staphylococcal abscesses by .sup.99m Tc-technetium-labelled liposomes," J. Med. Microbiol. 14:213-217 (1981).
Eisenhut, M. "Radiopharmaka fur die szintigraphische Tumordiagnostik," supplied by National Library of Medicine.
Osborne et al., "Radionuclide-Labelled Liposomes--A New Lymph Node Imaging Agent," Int'l J. of Nucl. Med. and Biol. 6:75-83 (1979).
Yu Bao-fa et al., "A New Lymph Node Imaging Agent-.sup.99m Tc-polyphase Liposome Oleatis (.sup.99m Tc-plo)," J. Oncol. (China) 10:270-273 (1988).
Farr et al., "99m-Technetium as a marker of liposomal deposition and clearance in the human lung," Int'l J. of Pharmaceutics 26:303-316 (1985).
Palmer et al., "The Mechanism of Liposome Accumulation in Infarction," Biochemica et Biophysica Acta 797:363-368 (1984).
Callahan et al., "A Modified Method for the In Vivo Labeling of Red Blood Cells with Tc-99m: Concise Communication," J. Nucl. Med. 23:315-318 (1982).
Dewanjee, M. K. "Binding of .sup.99m Tc Ion to Hemoglobin" J. of Nuclear Medicine 15(8):703-706 (1974).
Deliconstantinos et al., "Interaction of .sup.99m Tc-Labeled Liposomes With Walker Tumor Cell In Vitro. Liposome-Mediated Introduction of Thalblastine Into Resistant Walker Tumor Cells" Gen. Pharmac. 14(4):407-411 (1983).
Nakamura et al., "The behavior of .sup.99m Tc-hexamethylpropyleneamineoxime (.sup.99m Tc-HMPAO) in blood and brain" Eur. J. Nucl. Med. 15:100-107 (1989).
Unger et al., "Gadolinium-DTPA Liposomes as a Potential MRI Contrast Agent Work in Progress" Investigative Radiology 23(12):928-932 (1988).
Seltzer, S. E. "The Role of Liposomes in Diagnostic Imaging" Radiology 171(1):19-21 (1989).
Article in Radiology Today, Mar. 1989 "Indium-labeled liposomes effectively target secondary tumors" p. 3.
Article by Lang, Letters to the Editor, J. Nucl. Med., 31(6):1115 (1990).
Article by Ballinger, Letters to the Editor, J. Nucl. Med., 31(6):1116 (1990).
Article by Ballinger et al., "Technetium-99m HM-PAO Stereoisomers: Differences in Interaction with Glutathione", J. Nucl. Med., 29(12):1998-2000 (1988).
Klipper Robert W.
Phillips William T.
Rudolph Alan S.
Timmons James H.
Board of Regents , The University of Texas System
Covert John M.
Lovering Richard D.
The United States of America as represented by the Secretary of
LandOfFree
.sup.99m Tc labeled liposomes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with .sup.99m Tc labeled liposomes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .sup.99m Tc labeled liposomes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-766335