.sup.18 F-4-Fluoroantipyrine

Details .sup.18 F-4-Fluoroantipyrine .sup.18 F-4-Fluoroantipyrine

1981-05-29

1984-03-13

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 548375, A61K 4300, A61K 4900

Patent

active

044367171

ABSTRACT:
The novel radioactive compound .sup.18 F-4-fluoroantipyrine having high specific activity which can be used in nuclear medicine in diagnostic applications, prepared by the direct fluorination of antipyrine in acetic acid with radioactive fluorine at room temperature and purifying said radioactive compound by means of gel chromatography with ethyl acetate as eluent is disclosed. The non-radioactive 4-fluoroantipyrine can also be prepared by the direct fluorination of antipyrine in acetic acid with molecular fluorine at room temperature and purified by means of gel chromotography with ethyl acetate eluent.

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Shiue et al., J. Nucl. Med., 21:68-69, (1980).
Mantescu et al., Radiopharmaceuticals and Labelled Compounds, vol. 1, IAEA, Vienna, 1973, pp. 395-404.
The Chemistry of Radiopharmaceuticals, Masson publ., 1978, p. 118.
Endelman et al., Chem. Abstracts, vol. 86, 1977, abstract #139925a.

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