Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-03-25
1993-05-11
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
518213, A01N 4380
Patent
active
052100944
ABSTRACT:
A method of protecting 3-isothiazolones of the formula: ##STR1## wherein Y is (C.sub.1 -C.sub.18)alkyl or (C.sub.3 -C.sub.12)cycloalkyl each optionally substituted with one or more of hydroxy, halo, cyano, alkylamino, dialkylamine, arylamino, carboxy, carbalkoxy, alkoxy, aryloxy, alkylthio, arylthio, haloalkoxy, cycloaklylamino, carbamoxy, or isothiazolonyl; an unsubstituted or halo-substituted (C.sub.2 -C.sub.8) alkenyl or alkynyl; a (C.sub.7 -C.sub.10)aralkyl optionally substituted with one or more of halogen, (C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy; and an aryl optionally substituted with one or more of halogen, nitro, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkyl-acylamino, carb(C.sub.1 -C.sub.4)alkoxy or sulfamyl; and R and R.sup.1 is each independently H, halogen (C.sub.1 -C.sub.4) alkyl, (C.sub.4 -C.sub.8) cycloalkyl or joined together to form a phenyl; comprising incorporating therewith an effective amount of a sulphur-containing compound, or salt thereof, capable of reversibly forming an adduct with said isothiazolone. Stabilized isothiazolones and adducts with the sulfur-containing compound are also disclosed.
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Kathon 886 MW Microbicide and Kathon 893 MW Fungicide--Analysis in Metalworking Fluids by High Performance Liquid Chromatography 1988.
Fein Michael B.
Gerstl Robert
Rohm and Haas Company
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