Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-02-03
1983-04-26
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544 21, 544 16, 2602452R, 424270, 424271, C07D50157, A61K 31545
Patent
active
043813003
ABSTRACT:
Biologically active sulfur analogs of 6-aminopenicillanic acid having a nucleophile substituted in the 6- position are made by reacting a sulfenyl chloride with esters of diazopenicillanic acid. Biologically active sulfur analogs of 7-aminocephalosporanic acid having a nucleophile substituted in the 7- position are analogously made by reacting a sulfenyl chloride with esters of 7-diazocephalosporanic acid. Deacetoxycephalosporins can be formed from the corresponding analog of 6-aminopenicillanic acid and derivations thereof, by sulfoxide rearrangement of the thiazolidine ring of penicillins to the dihydrothiazine ring of cephalosporins. These nucleophile substituted sulfur analogs of penicillins and cephalosporins are new antibacterial agents and display antibacterial activity against a variety of microorganisms.
REFERENCES:
patent: 3159617 (1964-12-01), Sheehan
patent: 3206406 (1965-09-01), Pifferi
patent: 3868365 (1978-02-01), Dolfini et al.
patent: 3880834 (1975-04-01), Lunn
patent: 4020077 (1977-04-01), Cook et al.
patent: 4033979 (1977-07-01), Bentley et al.
patent: 4061629 (1977-12-01), Dolfini et al.
patent: 4062842 (1977-12-01), Dolfini et al.
patent: 4093625 (1978-06-01), Commons et al.
patent: 4265882 (1981-05-01), Sheehan et al.
patent: 4282149 (1981-08-01), Sheehan
D. H. R. Barton and T. G. Sammes, Proc. R. Soc. Lond. B, 179 345, (1971), (p. 3).
G. E. Gutowski, Tel. Lett., (1970), 1779 and 1863, (p. 3).
R. Riner and P. Zeller, Helv. Chim Acta, 51, 1905, (1968), (p. 3).
D. Hauser and H. P. Sigg, Helv. Chim Acta, 50, 1327, (1967), p. 4.
R. B. Morin and B. G. Jackson, "Chemistry of Cephalosporin Antibiotics", Progress in the Chem. of Org. Natural Products, XXVIII, Wein, Springer-Verlag, (1970), p. 4.
"Substituted Penicillin & Cephalosporin Derivatives, I. Stereospecific Introduction of the C-6(7) Methoxy Group," J. Amer. Chem. Soc., 94 1408, (1972), p. 4.
Edward H. Flynn, "Cephalosporins & Penicillin: Chemistry and Biology," Chapter 15, Academic Press, NY and London, (1972).
W. A. Spitzer and T. Goodson, Tet. Lett., No. 4, 273, (1973).
T. Jen, J. Frazee, J. R. E. Hoover, J. Org. Chem., 38, 2857, (1973).
W. A. Slusarchyk, et al., J. Org. Chem. 38, 943, (1973).
G. E. Gutowski, et al., Tet. Lett., (1971), 3429 and 3433.
Commons Thomas J.
Sheehan John C.
Massachusetts Institute of Technology
Neuner George W.
Rizzo Nicholas S.
Smith, Jr. Arthur A.
LandOfFree
Sulphur analogs of cephalosporins having a nucleophile substitut does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sulphur analogs of cephalosporins having a nucleophile substitut, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulphur analogs of cephalosporins having a nucleophile substitut will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1564353