Sulphonylbenzyl-substituted imidazoles

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 79, 514 85, 514 89, 514 91, 514 94, 514255, 5142358, 514381, 514397, 544139, 544337, 544370, 546210, 548111, 548112, 548252, 548253, 5483147, A61K 31535, A61K 31495, A61K 31415, C07D41312

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053189809

ABSTRACT:
Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary manner.
The sulphonylbenzyl-substituted imidazoles can be used as active compounds in medicaments.

REFERENCES:
patent: 5138069 (1992-08-01), Carini et al.
patent: 5185351 (1993-02-01), Finkelstein et al.
J. C. Sheehan, S. L. Ledis, J. Am. Chem. Soc. 95, 875 (1973).
F. E. Frerman et al., J. Biol. Chem. 258, 7087-7093 (1983).
N. B. Benoiton, K. Klurada, Int. Pept. Prot. Res. 17, 197 (1981).
R. Ross, J. Cell. Biol. 50, 172, 1971.

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