Sulphonylalkylamines, processes for the preparation thereof and

Details Sulphonylalkylamines, processes for the preparation thereof and Sulphonylalkylamines, processes for the preparation thereof and

1988-12-05

1990-08-14

Raymon, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560 12, 560 10, 562430, 564 86, 564 87, 564 88, 564 89, 564 92, 514602, 514603, 514605, 514562, 552 8, A61K 31215, C07C 6476

Patent

active

049488090

ABSTRACT:
The present invention provides sulphonylphenylalkylamines of the general formula: ##STR1## wherein R.sub.1 is an alkyl radical containing up to 6 carbon atoms, a cycloalkyl radical containing 3-7 carbon atoms or an aralkyl, aralkenyl or aryl radical, the aryl moiety, in each case, being optionally substituted one or more times by halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, hydroxyl, trifluoromethyl, cyano, nitro, amino, C.sub.1 -C.sub.6 alkylamino, C.sub.2 -C.sub.12 dialkylamino, C.sub.1 -C.sub.6 acylamino, C.sub.1 -C.sub.16 acyl or azide, R.sub.2 is a hydrogen atom, an alkyl radical containing up to 6 carbon atoms, an acyl radical or an aralkyl or aralkenyl radical, the aryl moiety, in each case, optionally being substituted one or more times by halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, hydroxyl, trifluoromethyl, cyano, nitro, amino, C.sub.1 -C.sub.6 alkylamino, C.sub.1 -C.sub.12 dialkylamino, C.sub.1 -C.sub.6 acylamino, C.sub.1 -C.sub.16 acyl or azide, B is an unbranched or branched alkylene chain with a maximum of 4 carbon atoms and A an alkyl or alkenyl radical containing up to 6 carbon atoms, a C.sub.1 -C.sub.6 formylalkyl radical, a C.sub.1 -C.sub.6 hydroxy-alkyl group or a radical --D--R.sub.3, in which D is a ##STR2## and R.sub.3 is a hydrogen atom, a C.sub.1 -C.sub.5 alkyl, a C.sub.1 -C.sub.5 hydroxyalkyl or a C.sub.1 -C.sub.5 alkylcarboxylic acid radical, as well as the pharmacologically acceptable salts thereof, the esters and amides thereof and the lactones of those compounds which contain a hydroxyl and a carboxyl group, with the exception of the compound benzene-sulphonic acid-(4-acetylphenethylamide).
The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.

REFERENCES:
patent: 4219668 (1980-08-01), Chiccarelli
patent: 4258058 (1981-03-01), Witte et al.
patent: 4443477 (1984-04-01), Witte et al.
patent: 4657929 (1987-04-01), Ince et al.
Chemical Abstracts, 106:46666 (1987).

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