Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2002-08-30
2010-02-16
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S145000
Reexamination Certificate
active
07662807
ABSTRACT:
The present invention provides photosensitizing agents obtained by reducing a single double bond in the porphyrin macrocycle of a sulphonated meso-tetraphenylporphyrin, preferably a disulphonated meso-tetraphenylporphyrin such as TPPS2a. The resulting sulphonated meso-tetraphenyl chlorins include compounds of formula (I) (wherein X is —SO3H; n, p, q and r are each independently 0 or 1; and the sum of n, p, q and r is an integer from 1 to 4, preferably at least 2, e.g. 2 or 4) isomers and isomer mixtures thereof. The compounds of the invention and their pharmaceutically acceptable salts find particular use as photosensitizing agents in the photochemical internalization of molecules and in photodynamic therapy.
REFERENCES:
patent: 05253466 (1992-03-01), None
patent: 2000007693 (2000-01-01), None
patent: 8901630 (1989-02-01), None
patent: 9607432 (1996-03-01), None
patent: 9830242 (1998-07-01), None
patent: 0054802 (2000-09-01), None
Woodburn et al., Int. J. Biochem. Cell Biol. vol. 27, No. 5, pp. 499-506, 1995.
Choi et al., “Counterion-Dependent Excitonic Spectra . . . ” J'nal of ACS'2003, 125(3), 810-820.
Pascu et al., “Photodynamic therapy studies . . . ”, Proceedings of SPIE, (1999), 4166, 138-148.
Hall et al., “Hard and soft porphyrins . . . ”, J'nal of Porphyrins and Phthalocyanines (2000), 4(3), 256-260.
Woodburn et al., “Effect of density-gradients on the binding of photosensitizing agents . . . ” Int'l J'nal of Biochemistry & Cell Biology, 1995 27(5), 499-506.
Human Gene Therapy 11:869-880 (Apr. 10, 2000).
J. Chem. Soc. 1957, 3461-3469.
International Search Report for PCT/GB02/03973 dated May 8, 2003.
Photochemistry and Photobiology, 2001, 74(2), 303-310.
Int. J. Cancer: 87, 853-859 (2000).
Photochemistry and Photobiology 1976, vol. 23, 337-341.
J. Chem. Soc. Perkin Trans. 2, 1999, 325-328.
Biochem J. (1989) 261, 277-280.
Br. J. Cancer (1991) 64, 1116-1120.
J. Org. Chem. 1962, 27, 3060-3062.
J. Chem. Soc. 1957, 733-739.
J. Am. Chem. Soc. 1969, 91(26), 7485-7489.
J. Chemical Physics 1955, 23(6), 1068-1078.
Cancer Research 1999, 59, 1180-1183.
Ravindra K. Pandey et al.; Alkyl Ether Analogs of Chlorophyll-a Derivatives: Part 1. Synthesis, Photophysical Properties and Photodynamic Efficacy; Photochemistry and Photobiology; 1996; 64(1), pp. 194-204.
Barbara W. Henderson et al.; An in vivo Quantitative Structure-Activity Relationship for a Congeneric Series of Pyropheophorbide Derivatives as Photosensitizers for Photodynamic Therapy; Cancer Research; 1997; 57(18); pp. 4000-4007.
Hungarian Patent Office Novelty Search Report; Application No. P0401434; Dated Apr. 1, 2008; only 1 page.
Kessel, et al. “Promotion of porphyrin cytotoxicity by ultrasound”; Optical Methods for Tumor Treatment and Detection, vol. 1645, 1992, pp. 82-90.
MacDonald, et al. “Subcellular Localization Patterns and Their Relationship to Photodynamic Activity of Pyropheophorbide-a Derivatives”; Photochemistry and Photobiology, vol. 70(5), 1999, pp. 789-797.
Berg, et al. “Cellular Uptake and Relative Efficiency in Cell Inactivation by Photoactivated Sulfonated meso-Tetraphenylporphines”; Photochemistry and Photobiology, vol. 52, No. 4, 1990, pp. 775-781.
Noodt, et al. “Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light”; British Journal of Cancer, vol. 79, 1999, pp. 72-81.
JP Publication No. 2000-007693; filed Jan. 22, 2000; Title: Chlorin Derivative; Abstract Only; 1 page.
Berg, et al; “Intracellular Localization of Sulfonated meso-Tetraphenylporphines in a Human Carcinoma Cell Line”; Photochemistry and Photobiology; 52; pp. 481-487; (1990).
Berg, et al; “Lysosomes as Photochemical Targets”; Int. J. Cancer; 59; pp. 814-822; (1994).
Berg Kristian
Rimington Claude
Rimington, legal representative Greta
Selbo Pal Kristian
Tran Diem Thuy Thi
Cantor & Colburn LLP
The Norwegian Radium Hospital Research Foundation
Ward Paul V.
Wilson James O.
LandOfFree
Sulphonated meso-tetraphenyl chlorins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sulphonated meso-tetraphenyl chlorins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulphonated meso-tetraphenyl chlorins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4206470