Sulphonamides for control of beta-amyloid production

Details Sulphonamides for control of beta-amyloid production Sulphonamides for control of beta-amyloid production

2007-04-17

2007-04-17

Witherspoon, Sikarl A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S084000, C564S086000, C514S601000, C514S602000, C514S603000

Reexamination Certificate

active

10484290

ABSTRACT:
There is disclosed a novel class of sulphonamido-substituted bridged bicycloalkyl derivatives comprising a substitute on the bridgehead position. The compounds modulate the production of the β-amyloid precursor protein, and hence are useful in the treatment of Alzheimer's Disease.

REFERENCES:
patent: 3836670 (1974-09-01), Freed et al.
patent: WO 01/70677 (2001-09-01), None
G. M. Rishton et al., “Fenchylamine Sulfonamide Inhibitors of Amyloid Beta Peptide Production by the Gamma-Secretase Proteolytic Pathway: Potential Small-Molecule Therapeutic Agents for the Treatment of Alzheimer's Disease”, J. Med. Chem., vol. 43, pp. 2297-2299 (2000).
K. Wiesner et al., “Synthesis and Rearrangement Control of Substituted Benzobicycloheptane Aziridines”, Can. J. Chem., vol. 51, pp. 1448-1457 (1973).
K. Wiesner et al., “Synthesis in the Series of Diterpene Alkaloids V. An Approach to Songorine”, Tetrahedron Letters, No. 14, pp. 1467-1470 (1966).

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