Sulphonamide derivatives as prodrugs of aspartyl protease...

Details Sulphonamide derivatives as prodrugs of aspartyl protease... Sulphonamide derivatives as prodrugs of aspartyl protease...

2005-01-04

2005-01-04

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S092000, C548S119000, C548S204000

Reexamination Certificate

active

06838474

ABSTRACT:
The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to pharmaceutical compositions comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to methods of treating mammals with these prodrugs and pharmaceutical compositions.

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