Sulphated vinyl polymers in compositions for treating retroviral

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer

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424 7835, A61K 3178, A61K 3174

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active

051529785

ABSTRACT:
Sulphated vinyl polymers such as sulphated polyvinylalcohol, sulphated copolymers of (meth)acrylic acid and vinylalcohol, and pharmaceutically acceptable salts thereof, have an antiviral effect against human immunodeficiency virus and may therefore be used as a therapeutic agent for treating retrovirus infections like AIDS and AIDS-related diseases. Their antiviral activity is apparently based on inhibition of virus adsorption; their inhibitory effect on giant cell formation is stronger than that of dextran sulphate.

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"Effect of 3'-Azido-2',3'-dideoxythymidine (AZT) and Neutralizing Antibody on Human Immunodeficiency Virus (HIV)-Induced Cytopathic Effects: Implication of Giant Cell Formation for the Spread of Virus In Vivo," Nakashima et al., Virology, 159, 169-173 (1987).
"Studies On The Chemistry Of Blood Coagulation," Chargaff et al., Department of Biological Chemistry and Surgeons, Columbia University, 155-161 (1936).
V. N. Tarasov et al., Tr. Inst. Poliomielita Virus . . . , vol. 16, pp. 308-318 (1971).
F. M. Hallinan et al., Cancer Biochem. Biophys. vol. 5, No. 2, pp. 97-101 (1981).

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