Sulfur-containing xanthine derivatives as adenosine antagonists

Details Sulfur-containing xanthine derivatives as adenosine antagonists Sulfur-containing xanthine derivatives as adenosine antagonists

1994-12-20

1995-09-26

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, 544268, C07D47306, A61K 3152

Patent

active

054534267

ABSTRACT:
The present invention provides sulfur-containing xanthine derivatives which are 1,3-disubstituted with a C.sub.1 -C.sub.12 alkyl, which may be further substituted with a hydroxy, amino, or halo group, and are 8-substituted with either a cycloalkyl, furyl, thienyl, or substituted phenyl group. These derivatives possess increased selectivity or potency at adenosine receptors.

REFERENCES:
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patent: 4564182 (1985-10-01), Kjellin et al.
patent: 4820709 (1989-04-01), Hofer
patent: 4879296 (1989-11-01), Daluge
patent: 4925847 (1990-05-01), Hofer
Chemical Abstracts vol. 111:77745(g) 1989.
Chemical Abstracts vol. 98 1252(z) (1983).
Chemical Abstracts vol. 98 125211z (1983).
Chemical Abstracts vol. 106 67009K (1987).

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