Sulfur-containing proanthocyanidin oligomer compositon and...

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from vitis

Reexamination Certificate

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Reexamination Certificate

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07833553

ABSTRACT:
Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.

REFERENCES:
patent: 5804597 (1998-09-01), Yamakoshi et al.
patent: 6528664 (2003-03-01), Romanczyk et al.
patent: 10-218786 (1998-01-01), None
patent: WO 03/024951 (2003-03-01), None
English translation of Torres (WO 03/024951-Mar. 2003).
Hong, Chuang-Ye, “The Inhibitory Effect of Tannins on Lipid Peroxidation of Rat Heart Mitochondria,” Journal of Pharmacy and Pharmacology, vol. 47 ( No. 2), p. 138-142, (Nov. 3, 1995).
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Hemingway, Richard W. et al., “Heterogeneity of interflavanoid bond location in loblolly pine bark procyanidins,” Phytochemistry, vol. 22 ( No. 1), p. 275-281, (Nov. 3, 1983).
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Geiss, Friederike et al., “Proanthocyanidins with (+)-epicatechin units fromByrsonima crassifoliabark,” Phytochemistry, vol. 39 ( No. 3), p. 635-643, (Nov. 3, 1995).
Tanaka, Takashi et al., “Chemical evidence for the de-astringency (insolubilization of tannins) of persimmon fruit,” Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry, p. 3013-3022, (Nov. 3, 1994).
Scholz, Eberhard et al., “Proanthocyanidins fromKrameria triandraroot,” Planta Medica, vol. 55 ( No. 4), p. 379-384, (Nov. 3, 1989).
Torres, J.L. et al., “Cysteinyl-flavan-3-ol Conjugates from Grape Procyanidins. Antioxidant and Antiproliferative Properties,” Bioorganic & Medicinal Chemistry, p. 2497-2509, (Nov. 3, 2002).

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