Sulfur-containing heterocyclic compounds useful for the treatmen

Details Sulfur-containing heterocyclic compounds useful for the treatmen Sulfur-containing heterocyclic compounds useful for the treatmen

1989-12-28

1991-12-10

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 79, 514212, 5142282, 5142335, 514253, 514275, 514316, 514324, 514361, 514363, 514364, 514365, 514367, 514370, 514377, 514380, 514431, 514432, 540542, 540546, 544 57, 544 62, 544145, 544243, 544322, 546 22, 546187, 546202, 548112, 548128, 548136, 548138, 548156, 548159, 548195, 548233, 548245, 548525, 549 5, 549 9, 549 23, 549 51, 549 53, A61K 31675, A61K 3167, C07D40900, C07D49500

Patent

active

050718410

ABSTRACT:
The present invention provides a sulfur-containing heterocyclic compound of the formula (I) ##STR1## wherein ring A is a benzene ring which may be substituted; R is a hydrogen atom or a hydrocarbon group which may be substituted; B is a carboxyl group which may be esterified or amidated; X is --CH(OH)-- or --CO--; k is 0 or 1; and k' is 0, 1 or 2 or a pharmaceutically acceptable salt thereof.
Also, it provides a process for producing the compound (I) or a salt thereof and a pharmaceutical preparation for use in the treatment of osteoporosis comprising the compound (I) or salt thereof.
The compounds (I) and salts thereof show excellent bone resorption inhibitory activity.

REFERENCES:
Neher et al., CA 73-28902b (1970).
Hori et al., CA 111-77940z (1989).
P. H. Bell et al., JACS, vol. 90, p. 2704 (1968).

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