Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-02-05
1998-07-21
Gerstl, Robert
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D41704
Patent
active
057837031
ABSTRACT:
A first embodiment of the invention relates to novel carbapenem compounds, (1R, 5S, methylcarbapen-2-em-3-carboxyic acid derivatives. These carbapenem compounds are represented by the following formula having a beta-coordinated methyl group introduced at the 1-position and a 2-position. ##STR1## In the formula, R is hydrogen; lower alkyl group which is unsubstituted or substituted by hydroxy, lower alkoxy or lower alkoxy-lower alkoxy group; group --COOR.sup.1 (R.sup.1 is hydrogen or lower alkyl group); or group --CONR.sup.2 R.sup.3 (R.sup.2 and R.sup.3 are, independently each other, hydrogen or lower alkyl), and Y is carboxy, --COO.sup..crclbar. or protected carboxy. These compounds are useful antibiotics for prevention and treatment of bacterial infections.
The second embodiment of the invention relates to 3-mercapto-1-(1,3-thiazolin-2-yl)azetidine represented by the following formula and its acid addition salts ##STR2## and to the production process therefor. The above compounds are useful as intermediates for preparing carbapenem compounds, which have strong antibacterial activity, with convenience and high yield.
REFERENCES:
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patent: 5534510 (1996-07-01), Abe
Patent Abstracts of Japan, vol. 13, No. 63, Feb. 13, 1989, JP 63-255280.
Chen, Bull Chem Soc. Japan III, (3) 762, 1968.
Abe Takao
Hayashi Kazuhiko
Isoda Takeshi
Kumagai Toshio
Mihira Ado
Gerstl Robert
Lederle (Japan) Ltd.
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