Sulfur compounds as inhibitors of hepatitis C virus NS3...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S331000

Reexamination Certificate

active

07816326

ABSTRACT:
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

REFERENCES:
patent: 5712145 (1998-01-01), Houghton et al.
patent: 6608027 (2003-08-01), Tsantrizos et al.
patent: 6911428 (2005-06-01), Zhu et al.
patent: 7012066 (2006-03-01), Saksena et al.
patent: 7244721 (2007-07-01), Saksena et al.
patent: 2007/0197448 (2007-08-01), Velazquez et al.
patent: WO 98/14181 (1998-04-01), None
patent: WO 98/17679 (1998-04-01), None
patent: WO 98/22496 (1998-05-01), None
patent: WO 99/07734 (1999-02-01), None
patent: WO 00/09543 (2000-02-01), None
patent: WO 00/09558 (2000-02-01), None
patent: WO 01/74768 (2001-10-01), None
patent: WO 01/77113 (2001-10-01), None
patent: WO 01/81325 (2001-11-01), None
patent: WO 02/08187 (2002-01-01), None
patent: WO 02/08244 (2002-01-01), None
patent: WO 02/08251 (2002-01-01), None
patent: WO 02/08256 (2002-01-01), None
patent: WO 02/48172 (2002-06-01), None
patent: WO 2005/087731 (2005-09-01), None
patent: WO 2006/130628 (2006-12-01), None
PCT International Search Report dated Mar. 25, 2009 for corresponding PCT Application No. PCT/US2008/004549.
Berenguer et al., “Hepatitis B and C Viruses: Molecular Identification and Targeted Antiviral Therapies”, Proceedings of the Association of American Physicians, 110(2):98-112 (1998).
Dimasi et al., “Characterization of Engineered Hepatitis C Virus NS3 Protease Inhibitors Affinity Selected from Human Pancreatic Secretory Trypsin Inhibitor and Minibody Repertoires”, Journal of Virology, 71(10):7461-7469 (1997).
Elzouki et al., “Serine Protease Inhibitors in Patients with Chronic Viral Hepatitis”, Journal of Hepatology, 27:42-48 (1997).
Failla et al., “Redesigning the Substrate Specificity of the Hepatitis C Virus NS3 Protease”, Folding & Design, 1(1):35-42 (1996).
Han et al., “α-Ketoamides, α-Ketoesters and α-Diketones as HCV NS3 Protease Inhibitors”, Bioorganic & Medicinal Chemistry Letters, 10:711-713 (2000).
Hoofnagle et al., “The Treatment of Chronic Viral Hepatitis”, The New England Journal of Medicine, 336(5):347-356 (1997).
Ingallinella et al., “Potent Peptide Inhibitors of Human Hepatitis C Virus NS3 Protease are Obtained by Optimizing the Cleavage Products”, Biochemistry, 37:8906-8914 (1998).
Kolykhalov et al., “Specificity of the Hepatitis C Virus NS3 Serine Protease: Effects of Substitutions at the 3/4A, 4A/4B, 4B/5A, and 5A/5B Cleavage Sites on Polyprotein Processing”, Journal of Virology, 68(11):7525-7533 (1994).
Komoda et al., “Substrate Requirements of Hepatitis C Virus Serine Proteinase for Intermolecular Polypeptide Cleavage inEscherichia Coli”, Journal of Virology, 68(11):7351-7357 (1994).
Landro et al., “Mechanistic Role of an NS4A Peptide Cofactor with the Truncated NS3 Protease of Hepatitis C Virus: Elucidation of the NS4A Stimulatory Effect via Kinetic Analysis and Inhibitor Mapping”, Biochemistry, 36:9340-9348 (1997).
Llinas-Brunet et al., “Peptide-Based inhibitors of the Hepatitis C Virus Serine Protease”, Bioorganic & Medicinal Chemistry Letters 8:1713-1718 (1998).
Marchetti et al., “Synthesis of Two Novel Cyclic Biphenyl Ether Analogs of an Inhibitor of HCV NS3 Protease”, Synlett S1:1000-1002 (1999).
Martin et al., “Design of Selective Eglin Inhibitors of HCV NS3 Proteinase”, Biochemistry, 37:11459-11468 (1998).
Martin et al., “Affinity Selection of a Camelized VHDomain Antibody Inhibitor of Hepatitis C Virus NS3 Protease”, Protein Engineering, 10(5):607-614 (1997).
Pizzi et al., “Molecular Model of the Specificity Pocket of the Hepatitis C Virus Protease: Implications for Substrate Recognition”, Proceedings of the National Academy Sciences of the USA, 91:888-892 (1994).
BioWorld Today, 9(217):1-5 (1998).
International Search Report for corresponding PCT Application No. PCT/US01/22678 dated Jun. 7, 2002.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Sulfur compounds as inhibitors of hepatitis C virus NS3... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sulfur compounds as inhibitors of hepatitis C virus NS3..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfur compounds as inhibitors of hepatitis C virus NS3... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4187266

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.