Sulfur analogues of 21-hydroxy-6,19-oxidoprogesterone...

Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing

Reexamination Certificate

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C514S179000, C514S180000, C552S510000, C549S029000, C549S041000

Reexamination Certificate

active

07053228

ABSTRACT:
The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.

REFERENCES:
patent: 6303591 (2001-10-01), Burton et al.
patent: 0 348 910 (1990-01-01), None
patent: 0 903 146 (1999-03-01), None
“Synthesis of 21-hydroxy-11,19-oxidopregn-4-ene-3,20-dione and 21-hydroxy-6,19-oxidopregn-4-ene-3,20-dione”; Steroids vol. 60, No. 3, pp. 268-271, 1995.
Burton et al.: “21-hydroxy-6,19-oxidoprogestrone: A novel synthetic steroid with specific antiglucocorticoid properties in the rats” Molecular Pharmacology, vol. 52, No. 4, pp. 743-753, Oct. 1, 1997.
D.B. Gowan: “Modifiers of steroid-hormone metabolism: A review of their chemistry, biochemistry and clinical applications” J. Steroid Biochem., vol. 5, pp. 501-523 1974.
Barry Forman et al.: “Nuclear hormone receptors activate direct, inverted, and everted repeats” Annals of New-York Academy of Science, vol. 761, pp. 29-37 1995.
Jeffrey L. Arriza et al.: “Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor” Science, vol. 237, pp. 268-275, 1987.
G. Teutsch et al.: “General structure-activity correlations of antihormones” Annals of New-York Academy of Science, vol. 761, pp. 5-28, 1995.
VIII International Congress of Pharmacology Tokyo, Japan Abstract, 1981.
Irvin M. Spitz et al.: “Mifepristone (RU 486)—A modulator of progestin and glucocorticoid actions” N. Engl. J. Med., vol. 329, pp. 404-412, 1993.
Carlos P. Lantos et al.: “Structure-activity relationship in certain glucocorticoids and mineralcorticoids” Physiopathology of Endocrine Disease and Mechanisms of Hormone Actions, pp. 477-494, 1981.
G. Burton et al.: “Sodium-retaining activity of some natural and synthetic 21-deoxysteroids” Mol. Pharmacol., vol. 47, pp. 535-543, 1995.
Adriana L. Brachet-Cota et al.: “An Improved preparation of 11,19-oxidopregn-4-ene-3,20-dione and 6,19-oxidopregn-4-ene-3,11,20-trione” Z. Naturforsch., vol. 45b, pp. 711-715, 1990.
Mario D. Galigniana: “Stability study on renal type I mineralocorticoid receptor” Life Science, vol. 59, pp. 511-521, 1996.
Christina R. McKittrick et al.: “Regulation of serotonergic function in the CNS by steroid hormones and stress” CNS Neurotransmittersand Nuromodulators, Neuroactive Steroids, pp. 37-76.
W.L. Duax et al.: “The mechanism of action of steroid antagonists: insights from crystallographic studies” J. Steroid Biochem., vol. 31, No. 48, pp. 481-492, 1988.
David H. Wagner, Jr., et al.: “Rescue of thymocytes from glucocorticoid-induced cell death mediated by DC28/CTLA-4 costimulatory interactions with B7-1/B7-2” J. Exp. Med., vol. 184, pp. 1631-1638, Nov. 1996.

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