Sulfotransferase inhibitor

Details Sulfotransferase inhibitor Sulfotransferase inhibitor

2008-07-08

2008-07-08

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S018200

Reexamination Certificate

active

10557652

ABSTRACT:
The hexuronic acid derivative represented by the following formula 1 or a salt thereof is used as an active ingredient of a heparin/heparan sulfate sulfotransferase inhibitor.In the formula, each of R1, R2, and R3independently represent(s) SO3−or H which may have a substituent, provided that at least one thereof represents SO3−; X represents OR4, SR4, N(R4)2, or C(R4)3, R4independently represents H, alkyl, alkenyl, alkynyl, acyl, aryl, or aralkyl group; one of R5and R6represents COOH while the other represents H; and the wavy line represents α-glycosidic bond or β-glycosidic bond.

REFERENCES:
patent: 5075433 (1991-12-01), Weis
patent: 5817487 (1998-10-01), Kobayashi et al.
patent: 5834282 (1998-11-01), Habuchi et al.
patent: 2004/0053253 (2004-03-01), Habuchi et al.
patent: 0 756 004 (1997-01-01), None
patent: 11-069983 (1999-03-01), None
patent: 2000-060566 (2000-02-01), None
patent: 2001-057882 (2001-03-01), None
patent: WO 99/50385 (1999-10-01), None
Rath et al. DDT vol. 9, No. 23, Dec. 2004, pp. 1003-1011.
Wessel et al. Carbohydrate Research 1995, 274, 1-9.
International Search Report dated Jul. 12, 2004.
Aikawa, et al. “Molecular Cloning and Expression of a Third Member of the Heparan Sulfate/Heparin GIcNAcN-Deacetylasel,”The Journal of Biological Chemistry, vol. 274, No. 5, pp. 2690-2695, Jan. 29, 1999.
Hashimoto, et al. “Molecular Cloning and Expression of Rat LiverN-Heparan,”The Journal of Biological Chemistry, vol. 267, No. 22, pp. 15744-16750, Aug. 5, 1992.
Hortin, et al. “Inhibitors of the Sulfation of Proteins, Glycoproteins, and Proteoglycans,”Biochemical and Biophysical Research Communications, vol. 150, No. 1, pp. 342-348, Jan. 15, 1988.
Ishihara, Masayuki. “Structural Requirements in Heparin for Binding and Activation of FGF-1 and FGF-4 are Different from that for FGF-2,”Glycobiology, vol. 4, No. 6, pp. 817-824, 1994.
Ishihara, et al. “Structural Features in Heparin Which Modulate Specific Biological Activities Mediated by Basic Fibroblast Growth Factor,”Glycobiology, vol. 4, No. 4, pp. 451-458, 1994.
Orellana, et al. “Molecular Cloning and Expression of a GlycosaminoglycanN-AcetylglucosaminylN-DeacetylaseIN-Sulfotransferase from a Heparin-Producing Cell Line,”The Journal of Biological Chemistry, vol. 269, No. 3, pp. 2270-2276, Jan. 21, 1994.
Sugumaran, et al. “Effects of Brefeldin A on the Localization of Chondroitin Sulfate-Synthesizing Enzymes,”The Journal of Biological Chemistry, vol. 267, No. 13, pp. 8802-8806, May 5, 1992.
Abstracts of the XV International Symposium on Glycoconjugates 1999; 16:S40.
Hashimoto, et al. “Molecular Cloning and Expression of Rat LiverN-Heparan,”The Journal of Biological Chemistry, vol. 267, No. 22, pp. 15744-15750, Aug. 5, 1992.
Bielicki, et al. “Human Liver Iduronate-2-Sulphatase,”Journal of Biochemistry, vol. 271, No. 1, pp. 75-86, 1990.
Supplementary European Search Report dated Apr. 16, 2007.
Ii, et al. “Characterization of Positional and Anomeric Isomers of Methyl 2-O- and 3-O-Sulfo-D-Glucopyranosiduronic Acids and Methyl 2-O- and 3-O-Sulfo-D-Glucopyranosides by Secondary Ion Mass Spectrometry,”Organic Mass Spectrometry, vol. 28, pp. 789-794, 1993.

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