Sulfonyloxy-biphenylcarboxylic ester derivatives which are inter

Details Sulfonyloxy-biphenylcarboxylic ester derivatives which are inter Sulfonyloxy-biphenylcarboxylic ester derivatives which are inter

1995-10-19

1996-12-24

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfonate esters

558 44, C07C40932

Patent

active

055875041

ABSTRACT:
The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: ##STR1## The 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative can be prepared in a high yield according to the present invention from a 2-amino-5-halogeno-3-nitropyridine derivative through amidation, N-alkylation and reductive cyclization.

REFERENCES:
patent: 5102880 (1992-04-01), Chakravarty et al.
patent: 5157026 (1992-10-01), Chakravarty et al.
patent: 5332744 (1994-07-01), Chakravarty et al.
Koch et. al., Synletters, pp. 34-35 (May 1994).
Organic Syntheses, Collective vol. 2, rev. of Annual Vol. X-XIX, pp. 134-137. (1980).
A. I. Meyers, et al., J. Org. Chem., vol. 39, No. 18, 1974, pp. 2778-2783.
Nicholas A. Cortese, et al., J. Org. Chem., vol. 42, No. 22, 1977, pp. 3491-3495.
Mervyn Israel, et al., Pyridopyrazines and Imidazopyridines, vol. 24, Oct. 1959, pp. 1455-1460.
Harold Graboyes, et al., Syntheses of Imidazopyridines and Pyridotriazoles, vol. 79, Dec. 20, 1957, pp. 6421-6427.
A. I. Meyers, et al., J. Org. Chem., vol. 43, No. 7, 1978, pp. 1372-1379.
Atwal, K. et al., J.Med.Chem. 1992, 35, (pp. 4751-4763).

Affiliated with

Also associated with

Rating

Sulfonyloxy-biphenylcarboxylic ester derivatives which are inter does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sulfonyloxy-biphenylcarboxylic ester derivatives which are inter, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfonyloxy-biphenylcarboxylic ester derivatives which are inter will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1179692