Sulfonylhydrazines and their use as antineoplastic agents and as

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

564 82, 564 95, 564 96, 564 98, C07C30300, C07C30700, C07C30900, C07C31100

Patent

active

051010720

ABSTRACT:
Sulfonylhydrazines of the formula RSO.sub.2 N(CH.sub.2 CH.sub.2 X)N(SO.sub.2 CH.sub.3).sub.2, wherein R is an alkyl or an aryl and X is a halogen or OSO.sub.2 Y, wherein Y is an alkyl or an aryl. Such sulfonylhydrazines are useful in treating cancer.
Methylating agents of the formula

REFERENCES:
patent: 4175200 (1979-11-01), Hunter et al.
patent: 4209632 (1980-06-01), Hunter
patent: 4849563 (1989-07-01), Sartorelli et al.
Isolation of Salivarian Trypanosomes from Man and other Mamals using DEAE-Cellulose, Sheila M. Lanham; Experimental Parasitology 28, 521-534 (1970).
Triazenes of Phenylbutyric, Hydrocinnamic, Phenoxyacetic, and Benzoylglutamic Acid Derivatives, Y. Sherly, J. Pharm. Sci. pp. 1192-1198, vol. 60, No. 8, Aug. 1971.
Parasitic Diseases, Michael Katz et al; pp. 164-172 Springer-Verlag.
Fatal attraction for the tsetse fly; Reg Allsopp et al, New Scientist 1985, pp. 41-43.
Parasitic Diseases, vol. 2, the Chemotherapy, Steven R. Meshnick, pp. 165-199, Chemotherapy of African Trypanosomiasis.
African Trypanosomiasis, Chap. 5, Manson's Tropical Diseases, 18th Edition, pp. 72-85.
1 Introduction to Parasitic Protozoa, The Biochemistry of Parasitic Protozoa, W. E. Gutteridge and G. H. Coombs, 1977, pp. 1-26.
Further Studies on Difluoromethylornithine in African Trypanosomes, P. P. McCann et al, Medical Biology 59: 434-440, 1981.
Efficacy of Combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis, Allen B. Clarkson, Jr. et al; Proc. Natl. Acad. Sci. U.S.A. Medical Services, vol. 80, pp. 5929-5733, Sept. 1983.
Evolutionary Trends in Mammalian Trypanosomes, Cecil A. Hoare, pp. 47-91.
Polyamine Depletion following Exposure to DL-.alpha.-Difluoromethylornithine Both in Vivo and In Vitro Initiates Morphological Alterations and Mitochondrial Activation in Monomorphic Strain of Trypanosoma brucei brucei, Bruce F. Giffin et al, J. Protozol. 33(2), 1986, pp. 238-243.
The Effect of DNA sequence, Ionic Strength and Cationic DNA Affinity Binders on the Methylation of DNA by N-Methyl-N-Nitrosourea; Chem. Res. Toxicol, 1988, 1. pp. 146-147.
Molecular and Biochemical Parasitology, 7 (1983) Elsevier Biomedical Press, pp. 209-255, Cyrus J. Bacchi et al, In vivo effects of -DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei.
Preclincal Investigation of Alkylating Agents in Cancer Chemotherapy, Abraham Goldin et al, pp. 954-1005.
Benzene Analogs of Triazenoimidazoles, J. Pharm. Sci. 1971, vol. 60, No. 9, Sep. 1971, pp. 1426-1428.
Separation of Trypanosomes from the Blood of Infected Rats and Mice by Anion-exchangers, Nature, vol. 218, Jun. 20, 1968, pp. 1273-1274.
Tropical Diseases Bulletin I. Salivaria, vol. 83, No. 2; 1986.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Sulfonylhydrazines and their use as antineoplastic agents and as does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sulfonylhydrazines and their use as antineoplastic agents and as, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfonylhydrazines and their use as antineoplastic agents and as will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2261061

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.