Sulfonyldihydrobenzimidazolone compounds as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S193000, C546S198000, C514S318000

Reexamination Certificate

active

07544701

ABSTRACT:
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

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Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Slassi et. al. “Recent Progress in the 5-HT6 receptor antagonists for the treatment of CNS diseases” Expert Opinion on therapeutic Patents 2002, 12, 513-527.
Sulfonyl Chlorides Available from Sigma-Aldrich (created by Examiner).
Jo{umlaut over ())}{umlaut over (})}rg Holenz, Petrus J. Pauwels, José Luis Di{acute over ())}{acute over (})}az, Ramon Mercer, Xavier Codony and Helmut Buschmann “Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents” Drug Discovery Today 2006, 11, 283-299.
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface p. 1-15.
Hauptman and Walter, Chem. Rev. 1962, 62, 347.
Fieser and Fieser, Reagents for Organic Synthesis, vol. 1 Wiley: NY, 1974, p. 723-730.
Mitchell and Lai Tetrahedron Letters 1980, 21, 2637.

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