Sulfonylaminovalerolactams and derivatives thereof as factor...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S301000, C514S307000, C514S314000, C514S315000, C514S321000, C514S322000, C514S326000, C514S343000, C514S422000, C514S424000, C544S353000, C546S114000, C546S146000, C546S172000, C546S192000, C546S193000, C546S198000, C546S199000, C546S208000, C546S211000, C546S278400, C548S518000, C548S528000

Reexamination Certificate

active

11611195

ABSTRACT:
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If:or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

REFERENCES:
patent: 7157470 (2007-01-01), Smallheer et al.
patent: 7169795 (2007-01-01), Han et al.
patent: 2002/0183324 (2002-12-01), Jacobson et al.
patent: 2005/0119266 (2005-06-01), Shi et al.
patent: WO03/049735 (2003-06-01), None
patent: WO03/050109 (2003-06-01), None
patent: WO03/053925 (2003-07-01), None
Elodi et al., “Optimization of conditions for the catalytic effect of the factor IXa-factor VIII Complex: Probable role of the complex in the amplification of blood coagulation”,Thromb. Res., vol. 15, pp. 617-629, 1979.

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