Sulfonylaminovalerolactams and derivatives thereof as factor...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S186000, C544S187000, C544S188000

Reexamination Certificate

active

10952396

ABSTRACT:
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia–If:or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

REFERENCES:
patent: 2002/0183324 (2002-12-01), Jacobson et al.
patent: 2004/0006062 (2004-01-01), Smallheer et al.
patent: WO 03/049735 (2003-06-01), None
patent: WO 03/050109 (2003-06-01), None
patent: WO03/053925 (2003-07-01), None
U.S. Appl. No. 10/952,397, filed Sep. 28, 2004, Han et al.
U.S. Appl. No. 10/952,204, filed Sep. 28, 2004, Shi et al.
Elodi et al., “Optimization of conditions for the catalytic effect of the factor IXa-factor VIII Complex: Probable role of the complex in the amplification of blood coagulation”,Thromb. Res., vol. 15, pp. 617-629, 1979.

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