Sulfonylamino substituted bicyclo [2.2.1]heptane hydroxamic acid

Details Sulfonylamino substituted bicyclo [2.2.1]heptane hydroxamic acid Sulfonylamino substituted bicyclo [2.2.1]heptane hydroxamic acid

1991-03-15

1992-08-11

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514575, 560312, 562621, 549463, A61K 31185, C07C25908

Patent

active

051379147

ABSTRACT:
Sulfonylamino substituted bicyclyl hydroxamic acid derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each is hydrogen or lower alkyl; R.sup.3 is hydrogen, lower alkyl, lower alkoxy, hydroxy or halogen; X is alkylene or alkenylene: Y is methylene or oxygen; and n is 0, 1, or 2, or the pharmaceutically acceptable salt thereof. These compounds have an advanced antagonistic activity to thromboxane A.sub.2 (TXA.sub.2)-receptor and are useful for the treatment of thrombosis, vasoconstriction, or bronchoconstriction, and the like disease which are induced by TXA.sub.2.

REFERENCES:
patent: 4654357 (1987-03-01), Nakane
patent: 4960909 (1990-10-01), Narisada et al.
Chemical Abstracts, vol. 112, No. 5, Jan. 29, 1990, Abstract No. 112:35549u.

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