Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-01-31
2006-01-31
McKane, Joseph K. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
06992193
ABSTRACT:
Sulfonylamino phenylacetamide derivatives of the general formulaare disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. In certain embodiments, the compounds of the invention that, preferably:(1) bind with high affinity to κ opioid receptors;(2) display good opioid receptor selectivity of κ versus μ and κ versus δ; and(3) do not substantially inhibit cytochrome P450 enzymatic activity, in particular CYP2D6, CYP2C9 and CYP3A4.
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Ajello Christopher William
Dolle Roland E.
Le Bourdonnec Bertrand
Adolor Corporation
McKane Joseph K.
Waller R.
Woodcock & Washburn LLP
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