Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-01-17
1997-06-17
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142378, 514445, 514539, 514602, 514603, 514604, 514605, 544160, 546194, 546234, 549 65, 560 13, 564 80, 564 84, 564 86, 564 87, 564 89, 564 90, 564 91, 564 93, 564 94, 564 95, 564 98, 564 99, A61K 3138, A61K 3144, A61K 3118
Patent
active
056397690
ABSTRACT:
Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
REFERENCES:
patent: H725 (1990-01-01), Gordon
patent: 4450164 (1984-05-01), Bristol et al.
patent: 4477441 (1984-10-01), Boger et al.
patent: 4514391 (1985-04-01), Gordon et al.
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4599198 (1986-07-01), Hoover
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4668769 (1987-05-01), Hoover
patent: 4668770 (1987-05-01), Boger et al.
patent: 4757050 (1988-07-01), Natarajan et al.
patent: 4880938 (1989-11-01), Freidinger
patent: 4963530 (1990-10-01), Hemmi et al.
patent: 4977277 (1990-12-01), Rosenberg et al.
Roberts et al, "Rational Design of Peptide-based Proteinase Inhibitors," Science, 248, 358 (1990).
Erickson et al, "Design Activity, and 2.8.ANG. Crystal Structure of a C.sub.2 Symmetric Inhibitor Complexed to HIV-1 Protease," Science, 249, 527 (1990).
Pearl et al, "Sequence specificity of retroviral proteases" Nature, 328, (1987).
Martin, Drugs of the Future, 16(3), 210-212 (1991).
Meek et al, Letter To Nature, 343, 90-92 (1990).
McQuade et al, Science, 247, 454-456 (1990).
Rich et al, Peptide Inhibitors of Proteases, 511-520 (1983).
Rosenberg et al. J. Med. Chem., 30, 1224-1228 (1987).
DeCrescenzo Gary A.
Freskos John N.
Getman Daniel
Mueller Richard A.
Talley John J.
G.D. Searle and Co.
O'Sullivan Peter
Ungemach Frank s.
LandOfFree
Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as r does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as r, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as r will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2158103