Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-06-23
2011-11-22
Andres, Janet (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S312000
Reexamination Certificate
active
08063220
ABSTRACT:
The present invention relates to new mGluR1 and mGluR5 receptor subtype preferring ligands of formula (I) and/or salts and/or hydrates and/or solvates and/or polymorphs thereof. The invention also relates to processes and intermediates for their preparation, to pharmaceutical compositions containing these compounds and to their use in treatment and/or prevention of conditions which require modulation of mGluR1 and mGluR5 receptors.
REFERENCES:
patent: 2006/0276469 (2006-12-01), Malherbe et al.
patent: 2009/0270371 (2009-10-01), Keseru et al.
patent: WO 2005/030129 (2005-04-01), None
patent: WO 2005/058834 (2005-06-01), None
patent: WO 2005/070890 (2005-08-01), None
patent: WO 2006/120573 (2006-11-01), None
Vippagunta et al., “Crystalline Solids” , 48 Adv. Drug Delivery Rev. 3-26 (2001).
Martin, Yvonne C. et al., Do Structurally Similar Molecules Have Similar Biological Activity?, 45 J. Med. Chem., 4350-4358, 4536 (2002).
Zhang et al., Structure-Activity Relationship in a Novel Series of 7-Substituted-Aryl Quinolines and 5-substituted-aryl Benzothiazoles at the Metabotropic Glutamate Receptor Subtype 5, 18 Bioorg. & Med. Chem. Letts., 3026-3035 (2010).
Aiba et al., “Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice,”Cell, 1994, 79:377-388.
Aiba et al., “Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice,”Cell, 1994, 79(2):365-375.
Bashir et al., “Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors,”Nature, 1993, 363:347-350.
Batra and Shea, “Novel trifunctional building blocks for fluorescent polymers,”Org. Lett., 2003, 5(21):3895-3898.
Birch et al., “Syntheses of flosequinan: a novel 4-quinolone shown to be useful in congestive heart failure,”J. Chem. Soc., Perkin Trans. 1, 1994, 387-392.
Bordi and Ugolini, “Group I metabotropic glutamate receptors: implications for brain diseases,”Progress in Neurobiology, 1999, 59:55-79.
Bordi and Ugolini, “Involvement of mGluR5 on acute nociceptive transmission,”Brain Res., 2000, 871:223-233.
Bortolotto et al., “A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation,”Nature, 1994, 368:740-743.
Cheng and Prusoff, “Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction,”Biochem. Pharmacol., 1973, 22:3099-3108.
Cunningham et al., “Excitatory amino acid receptors: a gallery of new targets for pharmacological intervention,”Life Sci., 1994, 54:135-148.
Gasparini et al., “[3H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5,”Bioorg. Med. Chem. Lett., 2002, 12:407-409.
Gasparini et al., “Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives,”Curr. Opin. Pharmacol., 2002, 2:43-49.
Hollmann and Heinemann, “Cloned glutamate receptors,”Annu. Rev. Neurosci., 1994, 17:31-108.
Johnson and Bunge, “Primary cell cultures of peripheral and central neurons and glia,”Protocols for Neural Cell Culture, 1992, Fedoroff and Richardson (eds.), The Humana Press Inc., pp. 51-77.
Joly et al., “Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1,”J. Neurosci., 1995, 15:3970-3981.
Knöpfel et al., “Metabotropic glutamate receptors: novel targets for drug development,”J. Med. Chem., 1995, 38(9):1417-1426.
Lavreysen et al., “[3H]R214127: A Novel High-Affinity Radioligand for the mGlu1 Receptor Reveals a Common Binding Site Shared by Multiple Allosteric Antagonists,”Mol..Pharm., 2003, 63(5):1082-1093.
Meller et al., “Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic glutamate receptors,”Neuroreport, 1993, 4:879-882.
Minakami et al., “Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5,”BBRC, 1994, 199:1136-1143.
Nakanishi, “Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity,”Neuron, 1994, 13(5):1031-1037.
Neugebauer, “Metabotropic glutamate receptors—important modulators of nociception and pain behavior,”Pain, 2002, 98:1-8.
Nishimura et al., “Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands,”Bioorg. Med. Chem. Lett., 2001, 11(9):1141-1144.
Pin and Duvoisin, “The metabotropic glutamate receptors: Structure and functions,”Neuropharmacology, 1995, 34:1-26.
Pin et al., “Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release inXenopus oocytes,”PNAS, 1992, 89:10331-10335.
Schoepp and Conn, “Metabotropic glutamate receptors in brain function pathology,”Trends Pharmacol. Sci., 1993, 14:13-20.
Schoepp, “Novel Functions for Subtypes of Metabotropic Glutamate Receptors,”Neurochem. Int., 1994, 24:439-449.
Slassi et al., “Recent advances in non-competitive mGlu5 receptor antagonists and their potential therapeutic applications,”Curr. Top. Med. Chem., 2005, 5(9):897-911.
Spooren et al., “Novel allosteric antagonists shed light on mGlu5 receptors and CNS disorders,”Trends Pharmacol. Sci., 2001, 22:331-337.
Tsou et al., “Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity,”J. Med. Chem., 2005, 48(4):1107-1131.
Bobok Amrita Agnes
Gal Krisztina
Galambos Janos
Keseru Gyorgy
Prauda Ibolya
Andres Janet
Fish & Richardson P.C.
Richter Gedeon Nyrt.
Rozof Timothy R
LandOfFree
Sulfonyl-quinoline derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sulfonyl-quinoline derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfonyl-quinoline derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4274180