Sulfonyl- or sulfinylbenzoylguanidine derivatives

Details Sulfonyl- or sulfinylbenzoylguanidine derivatives Sulfonyl- or sulfinylbenzoylguanidine derivatives

1996-08-09

1998-04-28

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564 85, 564 88, C07C28114, C07C32128

Patent

active

057446415

ABSTRACT:
4-Sulfonyl- or 4-sulfinylbenzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.6 and n have the meanings indicated, and their physiologically acceptable salts exhibit antiarrhythmic properties and, act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.

REFERENCES:
patent: 5091394 (1992-02-01), Englert et al.
patent: 5292755 (1994-03-01), Englert et al.
Noiri et al., "Cyclic RGE peptides ameliorate ischemic acute renal failure in rats," Kidney International, vol. 46, No. 4, Oct. '94, pp. 1050-1058.
Magazine et al., Evaluation of the Endothelin Receptor Populations Uisn Endothelin-1 Biotinylated at Lysine-9 Sidechain, Biochem. and Biophy. Res. Comm., vol. 181, No. 3, 1991, pp. 1245-1250.

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