Sulfonyl-N-hydroxyguanidine derivatives

Details Sulfonyl-N-hydroxyguanidine derivatives Sulfonyl-N-hydroxyguanidine derivatives

1997-11-20

1999-08-24

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514336, 514362, 514378, 514443, 514445, 514470, 514524, 514604, 5462804, 548126, 548247, 549 55, 549 65, 549466, 558413, 564 87, 564 89, 564 92, A61K 3118, A61K 3144, A61K 3142, A61K 3138, A61K 3134, C07C31164, C07C25550, C07C41304, C07D40904, C07D33372, C07D33334, C07D30782, C07D28514

Patent

active

059425466

ABSTRACT:
A compound of the formula: ##STR1## wherein X is arylene, heteroarylene, fused arylene, fused heteroarylene, or deleted; Y is sulfonyl, --O--, or deleted; R.sub.1 is aryl, heteroaryl, fused aryl, or fused heteroaryl; R.sub.2 is H, lower alkyl, lower alkoxy, halo, nitro, cyano, haloalkyl, hydroxyl, carboxyl, amido, amino, or aminoalkyl; or a salt thereof are disclosed. Also disclosed are a pharmaceutical composition which contains an excipient and an effective amount of a compound of the above formula and a method of treating cancer which involves the administration of an effective amount of such a compound to a patient in need thereof.

REFERENCES:
patent: 5234955 (1993-08-01), Ray et al.
patent: 5262440 (1993-11-01), Ehlhardt et al.
Chern et al., "Synthesis and Cytotoxic Evaluation of Substituted Sulfonyl-N-hydroxyguanidine Derivatives as Potential Antitumor Agents," J. Med. Chem., 40:2276-2286, 1997.

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