Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-11-02
2009-10-06
Anderson, Rebecca L (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S394000
Reexamination Certificate
active
07598393
ABSTRACT:
This invention relates to compounds of the formula (I):or a pharmaceutically acceptable salt thereof, wherein A, B, R1, R2and R3are each as described herein, and compositions containing such compounds, and the use of such compounds in the treatment of a condition mediated by CB2 receptor activity.
REFERENCES:
patent: 4177057 (1979-12-01), Hunter et al.
patent: 5702877 (1997-12-01), Odenwalder et al.
patent: 5972968 (1999-10-01), deNanteuil et al.
patent: 6106864 (2000-08-01), Dolan et al.
patent: 6352985 (2002-03-01), Yamasaki et al.
patent: 6815456 (2004-11-01), Zhou et al.
patent: 2004/0138286 (2004-07-01), Imazaki et al.
patent: 2006/0111402 (2006-05-01), Ng et al.
patent: 2006/0116412 (2006-06-01), Ng et al.
patent: 1198633 (1967-11-01), None
patent: WO 9111172 (1991-08-01), None
patent: WO 9402518 (1994-02-01), None
patent: WO 9855148 (1998-12-01), None
patent: WO 0035298 (2000-06-01), None
patent: WO 0116097 (2001-03-01), None
patent: WO 0157020 (2001-08-01), None
patent: WO 0246168 (2002-06-01), None
patent: WO 02059088 (2002-08-01), None
patent: WO 02085866 (2002-10-01), None
patent: WO 2005002520 (2005-01-01), None
patent: WO 2005030732 (2005-04-01), None
patent: WO 2005030733 (2005-04-01), None
patent: WO 2005030761 (2005-04-01), None
patent: WO 2005030762 (2005-04-01), None
Cecil Textbook of Medicine, 20th edition (1996), vol. 2, pp. 2050-2057.
Cecil Textbook of Medicine, 20th edition (1996), vol. 2, pp. 1992-1996.
FDA mulls drug to slow late-stage Alzheimer's [online], [retrieved on Sep. 23, 2003]. Retrieved from the Internet, URL; http://www.cnn.com/2003/HEALTH/condtions/09/24/alzheimers.drug.ap/indexhtml>.
Lupus erythematosus [online], [retrieved on Dec. 28, 2006]. Retrieved from the Internet, URL; http://en.wikipedia.org/wiki/Lupus—erythematosus>.
Neurodegenerative disease [online], [retrieved on Jul. 21, 2006]. Retrieved from the Internet, URL;http://en.wikipedia.org/wiki/Neurodegenerative—disease>.
Pain Management: Neuropathich Pain [online], retreived on Dec. 30, 2008 and retrieved from URL (http;//www.medicinenet.com/script/main/art.asp?articlekey=42085).
Vincek, W. C., et at,Importance of the Aromatic Ring in Adrenergic Amines. 5 Nonaromatic Analogues of Phenylethanolamine as Inhibitors of Phenylethanolamine N-Methyilransferase: Role of Hydrophobic and Steric Interactions,J. Med. Chem., vol. 24, pp. 7-12, (1981).
Dutch Search report in Appln. No. 1030324 (2006).
FR 1 481 049 with English translation of claims.
PCT International Search Report for International Application No. PCT/IB2005/003325: Family member of U.S. Appl. No. 11/266,107 (2006).
Blazejewski, J. C., et al.,2-Triftuoromethoxyethyl Trillate: A Versatile Trifluolomethoxyethyl Canter,J. Org. Chem, vol. 66, pp. 1061-1063, (2001).
Davis, D. P., et al.,Importance of the Aromatic Ring in Adrenergic Amines. 6. Nonaromatic Analogues of Phenylethanolamine as Inhibitors of Phenylethanolamine N-methyltransferase: Role of π-Electronic and Staric Interactions,J. Med. Chem., vol. 24. pp. 12-16, (1981).
Finnin, B., C., et at.,Transdermal Penetration Enhancers: Applications, Limitations, and Potential,Journal of Pharmaceutical Sciences, vol. 88, No. 10, pp. 955-958, (1999).
Hildbrand, S., et al.,5-Substituted 2-Aminopyridine C-Nucleosides as Protonated Cytidine Equivalents: Increasing Efficiency and Selectivity in DNA Triple-Helix Formation,J. Am. Chem. Soc., vol. 119, pp. 5499-5511, (1997).
Hohmann, A. G., et al.,Selective Activation of Cannabinoid CB2Receptors Suppresses Hyperalgesia Evoked by Intradermal Capsaicin,Journal of Pharmacology and Experimental Therapeutics, vol. 308, No. 8, pp. 446-453, (2004).
Ibrahim, M. M., et al.,Activation of CB2cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS,PNAS, vol. 100, No. 18, pp. 10529-10533, (Sep. 2, 2003).
Kubo, K., et al.;Synthesis of 2[[(4-Fluoroalkoxy-2-pyridyl)methyl]suffinyI]-iH-benzimidazoles as Antiulcer Agents,Chem. Pharm. Bull., vol. 38, No. 10, pp. 2853-2858, (1990).
Landini, D., et al.,Nucleophilic Aromatic Substitution Reactions under Phase-Transfer Conditions. Synthesis of Alkyl Aryl Sulfides from Isomeric Dichlorobenzenes and Thiolates, J. Org. Chem., vol. 48, pp. 604-605, (1983).
Liang, A. C., et al.,Fast-dissolving intraoral drug delivery systems, Expert Opinion Ther. Patents, vol. 11, No. 6, pp. 981-986, (2001).
Mathison, R., et al.,Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats, British Journal of Pharmacology, vol. 142, pp. 1247-1254, (2004).
Mizerski, A., et al.,Benzoimidazole derivatives containing fluoro-, difluoro-and trifluoromethylsulfonyl groups as new compounds with biological activity, Chemical & Environmental Research, vol. 11, Nos. 1 & 2), pp. 63-75, (2002).
Mizerski, A., et al.,Transformations of Chlorodifluoromethyl-4-chlorophenyl sulfone into new compounds with pesticidal activity, Polish Journal of Applied Chemistry, XLVII, No. 3, pp. 161-167, 2003.
Satyamurthy, N., et al.,Synthesis and stereochemistry of 1-oxa-6-heteraspiro[2.5]octanes. Single-crystal analysis of 6-pheny1-1-oxa-6-phosphasping[2.5]octane 6-sulfide, Phosphorous and Sulfur, vol. 19, pp. 113-129, (1984).
Verma, R., et al.,Current Status of Drug Delivery Technologies and Future Directions, Pharmaceutical Technology On-Line, vol. 25, No. 2, pp. 1-14, (2001).
Wesselmann, U., et al.,Uterine inflammation as a noxious visceral stimulus: behavioral characterization in the rat, Neuroscience Letters, vol. 246, pp. 73-76, 1998.
Yamamoto, T., et al.,Condensation of thiophenols with aryl halides using metallic copper as a reactant. Intermediation of cuprous thiphenolates, Can. J. Chem, vol. 62, pp. 1544-1547, (1984).
Yee, S., In VitroPermeability Across Caco-2 Cells(Colonic)Can Predictin Vivo (Small Intestinal)Absorption in Man—Fact or Myth, Pharmaceutical Research, vol. 14, No. 6, (1997).
Kon-I Kana
Matsumizu Miyako
Shima Akiko
Anderson Rebecca L
Benson Gregg C.
Olson A. Dean
Pfizer Inc.
Young Shawquia
LandOfFree
Sulfonyl benzimidazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sulfonyl benzimidazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfonyl benzimidazole derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4127023