Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-10-17
2006-10-17
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S120000
Reexamination Certificate
active
07122557
ABSTRACT:
The present application describes sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds and derivatives thereof of Formula I:in-line-formulae description="In-line Formulae" end="lead"?P4-P-M-M4Iin-line-formulae description="In-line Formulae" end="tail"?or pharmaceutically acceptable salt forms thereof, wherein M is a ring, P is an optional ring, and P4and M4are as defined below. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
REFERENCES:
patent: 3340269 (1967-09-01), Blatter
patent: 3365459 (1968-01-01), Blatter
patent: 3423414 (1969-01-01), Blatter
patent: 5342851 (1994-08-01), Sanfilippo et al.
patent: 5976532 (1999-11-01), Coller et al.
patent: 5998424 (1999-12-01), Galemmo, Jr. et al.
patent: 6020357 (2000-02-01), Pinto et al.
patent: 6060491 (2000-05-01), Pruitt et al.
patent: 6191159 (2001-02-01), Pinto
patent: 6413980 (2002-07-01), Fevig et al.
patent: 6750225 (2004-06-01), Pinto et al.
patent: WO 98/28269 (1998-07-01), None
patent: WO 98/28282 (1998-07-01), None
patent: WO 98/57934 (1998-12-01), None
patent: WO 98/57937 (1998-12-01), None
patent: WO 98/57951 (1998-12-01), None
patent: WO 99/32454 (1999-07-01), None
patent: WO 99/32477 (1999-07-01), None
patent: WO 99/50255 (1999-10-01), None
patent: WO 00/39108 (2000-07-01), None
patent: WO 00/39131 (2000-07-01), None
patent: WO 00/59902 (2000-10-01), None
patent: WO 01/05784 (2001-01-01), None
patent: WO 01/19798 (2001-03-01), None
patent: WO 01/32628 (2001-05-01), None
Fevig, et al, STN International (2006) HCAPLUS Database, Columbus, OH, Accession No. 2000:457072.
Freistein, STN International Search Report, Jan. 9, 2006.
Bauer, K.A., “Fondaparinux: a new synthetic and selective inhibitor of Factor Xa”, Best Practice & Research Clinical Haematology, vol. 17, No. 1, pp. 89-104, 2004.
Elodi et al., “Optimization of Conditions for the Catalytic Effect of The Factor IXa—Factor VIII Complex: Probable role of the complex in the amplification of blood coagulation”, Thrombosis Research, vol. 15, pp. 617-623, 1979.
Gresele et al., “Novel approaches to the treatment of thrombosis”, TRENDS in Pharmacological Sciences, vol. 23, No. 1, pp. 25-32, Jan. 2002.
Kaiser, B., “Visions & Reflections—Factor Xa—a promising target for drug development”, Cell. Mol. Life Sci., vol. 59, pp. 189-192, 2002.
Linkins et al., “New Anticoagulants”, Seminars in Thrombosis and Hemostasis, vol. 29, No. 6, pp. 619-631, 2003.
Rauch et al., “Thrombus Formation on Atherosclerotic Plaques: Pathogenesis and Clinical Consequences”, Annals of Internal Medicine, vol. 134, No. 3., pp. 224-238, Feb. 6, 2001.
Ruef et al., “New antithrombotic drugs on the horizon”, Expert Opin. Investig. Drugs, vol. 12, No. 5, pp. 781-797, 2003.
Wang et al., “Inhibition of Factor Xa Reduces Ischemic Brain Damage After Thromboembolic Stroke in Rats”, Stroke, pp. 468-474, Feb. 2003.
Weitz et al., “Thrombophilia and New Anticoagulant Drugs”, Hematology, pp. 424-438, 2004.
Wong et al., “Nonpeptide Factor Xa Inhibitors III: Effects of DPC423, an Orally-Active Pyrazole Antithrombotic Agent, on Arterial Thrombosis in Rabbits”, vol. 303, No. 3, pp. 993-1000, 2002.
Gungor Timur
Lam Patrick Y. S.
Li Yun-Long
Pinto Donald J.
Qiao Jennifer X.
Bristol--Myers Squibb Company
Freistein Andrew B.
Saeed Kamal A.
Sun Jing G.
Vance David H.
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