Sulfonate ACAT inhibitors

Details Sulfonate ACAT inhibitors Sulfonate ACAT inhibitors

1994-12-19

1996-04-23

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514510, 514513, 514300, 514404, 514312, 514457, 514341, 514256, 514252, 514314, 514246, 514248, 514259, 514274, 514351, 514387, 514445, 514443, 514473, 514470, 514469, 514247, 514255, 514424, 514407, 514372, 514365, 514376, 514380, 514384, 514359, 514392, 514386, 514367, 514418, 514415, 514311, 514309, 514307, 558 50, 558 49, 558 52, 546122, 546153, 546294, 546157, 546172, 546141, 546147, 546146, 5483701, 5483704, 548550, 548551, 548213, 548187, 548228, 548229, 548243, 548255, 5482644, 5483241, 548166, 5481

Patent

active

055103790

ABSTRACT:
.beta.-Carboxy sulfonates of the formula ##STR1## wherein R.sub.1 is aryl, R.sub.3 and R.sub.4 are hydrogen or alkyl, Y is -O-, -S-, or -NR.sub.2 -, and R.sub.5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hypercholesterolemia and atherosclerosis.

REFERENCES:
patent: 4567004 (1986-01-01), Blank et al.

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