Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2006-04-18
2006-04-18
Dentz, Bernard (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C514S082000, C514S089000, C514S095000, C514S096000, C514S092000, C514S093000, C514S094000, C514S099000, C546S023000, C546S024000, C546S025000, C546S022000, C544S243000, C548S112000, C548S113000, C549S006000, C549S220000, C549S222000, C558S169000, C558S173000
Reexamination Certificate
active
07030103
ABSTRACT:
The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not require a β-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
REFERENCES:
patent: 3870771 (1975-03-01), Golborn et al.
patent: 3959551 (1976-05-01), Golborn et al.
patent: 4031170 (1977-06-01), Birum
patent: 4032601 (1977-06-01), Birum
patent: 5681821 (1997-10-01), Powers et al.
patent: 6075014 (2000-06-01), Weston et al.
patent: 2 261 081 (1972-12-01), None
patent: 261073 (1988-03-01), None
patent: 505122 (1992-09-01), None
patent: 805147 (1997-11-01), None
patent: 1367677 (1974-09-01), None
patent: 5490160 (1979-07-01), None
patent: 62126160 (1987-06-01), None
patent: 9532947 (1995-12-01), None
patent: 9729080 (1997-08-01), None
patent: WO 99/33850 (1999-07-01), None
patent: WO 00/04030 (2000-01-01), None
Dai Q and Chen RY. Gaodeng Xuexia Huaxue Xuebao (1997), 18(12), 1992-1994.
Mikolajczyk M et al. Tetrahedron: Asymmetry (1997), 8(24), 3991-3994.
Chen RY and Dai Q. Chin. Chem. lett. (1955), 6(7), 561-564.
Cremlyn RJ et al. Phosphorus Sulfur (1979), 5(3), 277-86.
Cremlyn RJW et al. Phosphorus (1976), 6(3-4), 207-13.
Pine SH. Organic Chemistry. Fifth Edition. Inside page of cover.
Ovrutskii et al. Khimiko-Farmatsevticheskii Zhurnal (1990), 24(4), 12-14.
Cohen, Science, 257:1051-1055 (1992).
Neu, Science, 257:1064-1073 (1992).
Coulton et al., Progress in Medical Chemistry, 31:297-349 (1994).
Dudley, Pharmacotherpy, 15:9S-14S (1995).
Sutherland, Trends Pharmacol. Sci., 12:227-232 (1991).
Li et al., Bioorg. Med. Chem., 5(9):1783-1788 (1997).
Dryjanski and Pratt, Biochemistry, 34:3569-3575 (1995).
Ghysen, Prospect Biotechnol., 128:67-95 (1987).
Black et al., Current Pharmaceutical Design, 4:133-134 (1998).
Dalbey et al., Protein Science, 6:1129-1138 (1997).
Waley, The Chemistry of B-Lactamase, Page Ed., Chapman & Hall, London, 198-228 (1992).
March, Advanced Organic Chemistry, Third Edition, John Wiley & Sons, 310-316 (1985).
Nikaido and Vaara, Microbiological Review, 49:1-32 (1985).
Livermore, Scad. J. Infect. Dis., Suppl., 74:15-22 (1991).
Goodman and Gilmans, The Pharmacological Basis of Therapeutics, 8thEd., “Biotransformation of Drugs”, McGraw Hill, Int, Ed., 13-15 (1995).
Payne et al., Antimicrobial Agents and Chemotherapy, 38:767-772 (1994).
Hanaki et al., Antimicrobial Agents and Chemotherapy, 30:1120-1126 (1995).
S.L. Graham et al., J. Med. Chem., 32:2548 (1989),
Dryjanski et al., “Inactivation of the Enterobacter cloacae P99 Lactamase by a Flourescent Phosphonate: Direct Detection of Ligand Binding at the Second Site”, Biochemistry, 34:3569-3575, 1995.
Li et al., “Structure-Activity Studies of the Inhibition of Serine Lactamases by Phosphonate Monoesters,”Bioorganic & Medicinal Chemistry, 5:1783-1788, 1997.
Jackson et al., “Synthesis and Evaluation of Diphenyl Phosphonate Esters as INhibitos of the Trypsin-like Granzyms A and K and Mast Cell Tryptase”, Journal of Medicinal Chemisrty, 41:2289-2301.
Chen et al., “The Synthesis of Novel Phosphonodipeptides and Their Herbal Activity”, Heteroatom Chemistry, 4: 1-5.
Chen, Study on the Mannich-Type Reaction of P-Toluenesulfonamide, Chinese Chemical Letters, 6:181-184.
Besterman Jeffrey M.
Delorme Daniel
Rahil Jubrail
Dentz Bernard
Keown Wayne A.
Keown & Associates
Methylgene Inc.
Zucchero Joseph C.
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