Sulfonamidocarboxamides

Details Sulfonamidocarboxamides Sulfonamidocarboxamides

1997-06-04

1998-06-09

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

546233, 546247, C07D26530

Patent

active

057636044

ABSTRACT:
Sulfonamidocarboxamides of the formula ##STR1## wherein A, M, Q, X and Y have the significance given in the description, as well as hydrates, solvates and salts thereof, which inhibit thrombin-induced blood platelet aggregation and clotting of fibrinogen in plasma, as described. The compounds of formula I can be prepared by amidination of a cyclic amino group standing for grouping X or by C(O)N(Q) amide formation.

REFERENCES:
CA 116: 214908 Preparation of (aminoheterocyclylmethyl)amino acid sulfonamides and related compounds as thrombin inhibitors. Ackerman et al., Jan. 29, 1992.

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