Sulfonamidocarboxamides

Details Sulfonamidocarboxamides Sulfonamidocarboxamides

1996-08-13

1997-10-14

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

546246, C07D21114, C07D26530

Patent

active

056774486

ABSTRACT:
Sulfonamidocarboxamides of the formula ##STR1## wherein A, M, Q, X and Y have the significance given in the description, as well as hydrates, solvates and salts thereof, which inhibit thrombin-induced blood platelet aggregation and clotting of fibrinogen in plasma, as described. The compounds of formula I can be prepared by amidination of a cyclic amino group standing for grouping X or by C(O)N(Q) amide formation.

REFERENCES:
patent: 4227006 (1980-10-01), Okamoto et al.
patent: 4258192 (1981-03-01), Okamoto et al.
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 5037808 (1991-08-01), Tjoeng et al.
patent: 5053393 (1991-10-01), Tjoeng et al.
patent: 5260307 (1993-11-01), Ackermann et al.
patent: 5405854 (1995-04-01), Ackermann et al.
CA 121:83062n N-Amidinopiperidinyl-(3/4)-or . . . inhibitors. Ackermann et al., p. 1077, 1994.
J. Med. Chem. 33, 1990, 1406-1413.
Biochem. J. 55, 1955, 170-171.
J. Heterocycl. Chem. 23, 1986, 929-933.
J. Med. Chem. 1980, 23, 1293-1299, vol. 12.
Pharmazie 39, 1984, 226-230.
Thrombosis & Haemotasis 67, 1992, 56-59.
Drugs of the Future, 17, 1992, 1087-90.
CA 116:214908q, Preparation Inhibitors, Ackermann, et al. p. 792, 1992.

Affiliated with

Also associated with

Rating

Sulfonamidocarboxamides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sulfonamidocarboxamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sulfonamidocarboxamides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1556514