Sulfonamido derivatives inhibiting the aldose reductase enzyme s

Details Sulfonamido derivatives inhibiting the aldose reductase enzyme s Sulfonamido derivatives inhibiting the aldose reductase enzyme s

1988-09-16

1990-05-22

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549392, 549393, A61K 3135, C07D31186

Patent

active

049278495

ABSTRACT:
The xanthosulfonamido and benzensulfonamido derivatives corresponding to the formula: ##STR1## wherein x represents hydrogen, alkyl, alkoxy or halogen, Y represents an alkyl, alkoxy or halogen and Z represents the group ##STR2## or Y and Z taken together form the group: ##STR3## wherein R.sub.1 in turn is a group selected among electron attracting groups, halogens and the group: ##STR4## itself, possess activity in inhibiting the aldose-reductase enzyme system and are thus useful in the treatment of the complications, at the eye and peripheral neuropathy levels, as induced by diabetes.

REFERENCES:
patent: 3678077 (1972-07-01), Nakanishi et al.
patent: 3849565 (1974-11-01), Pfister et al.

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