Sulfonamide-substituted fused 7-membered ring compounds,...

Details Sulfonamide-substituted fused 7-membered ring compounds,... Sulfonamide-substituted fused 7-membered ring compounds,...

2005-06-21

2005-06-21

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C514S601000, C514S602000, C514S603000, C514S604000, C514S605000, C564S079000, C564S080000, C564S081000, C564S082000, C564S084000, C564S085000, C564S086000, C564S087000, C564S089000, C564S090000, C564S091000, C564S092000, C564S095000, C564S096000, C564S097000, C564S098000, C564S099000

Reexamination Certificate

active

06908947

ABSTRACT:
The present invention relates to compounds of formula I,in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in pharmaceuticals. The compounds effect the potassium channel or the IKschannel opened by cyclic adenosine monophosphate (cAMP) and are outstandingly suitable as pharmaceutical active compounds, for example for the prophylaxis and therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal disorders.

REFERENCES:
patent: 5258510 (1993-11-01), Ogawa et al.
patent: 6333337 (2001-12-01), Gross et al.
patent: 0 370 901 (1990-05-01), None
patent: 0 389 861 (1990-10-01), None
patent: WO 94/13292 (1994-06-01), None
patent: WO 95/14470 (1995-06-01), None
Derek R. Buckle et al., “Conformational and Steric Modifications of the Pyran Ring of the Potassium-Channel Activator Cromakalim,”J. Chem. Soc. Perkin Trans. 1, pp. 2763-2771 (1991).
Colatsky, Thomas J. and Thomas M. Argentieri, “Potassium Channel Blockers as Antiarrhythmic Drugs,”Drug Development Research, vol. 33, pp. 235-249 (1994).
Lohrmann, E. et al., “A new class of inhibitors of cAMP-medicated C1−secretion in rabbit colon, acting by the reduction of cAMP-activated K+conductance,”Pflügers Archiv-European Journal of Physiology, vol. 429, p. 517-530 (1995).
R. M. Soll et al., “N-Sulfonamides of Benzopyran-Related Potassium Channel Openers: Conversion of Glyburide Insensitive Smooth Muscle Relaxants to Potent Smooth Muscle Contractors,”Bioorganic&Medicinal Chemistry Letters, vol. 4, No. 5, pp. 769-773 (1994).

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