Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-02-19
2000-06-06
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514821, 514867, 514925, 514926, 549399, 549404, A01N 4316, C07D31174, C07D31176
Patent
active
060719532
ABSTRACT:
Chromans of formula I ##STR1## with the meanings of R(A), R(B) and R(1) to R(8) stated in the specification are suitable for producing a medicament for blocking the K.sup.+ channel that is opened by cyclic adenosine monophosphate (cAMP); also for producing medicaments for inhibiting gastric acid secretion; for the treatment of ulcers of the stomach and the intestinal region, in particular the duodenum, for the treatment of reflux esophagitis, for the treatment of diarrheal disorders, for the treatment and prevention of all types of arrhythmias, including atrial, ventricular and supraventricular arrhythmias, for controlling reentry arrhythmias and for preventing sudden heart death as a result of ventricular fibrillation.
REFERENCES:
Wargh et al, Chemical Abstract vol. 125 No. 191888, "The cAMP-Regulated & 293 B-Inhibited K.sup.+ Conductance of Rat Colonic Crypt Base Cells." 1996.
Lohrmann et al, Chemical Abstract vol. 123 No. 160095, "A New Class of Inhibitors of cAMP-Mediated C1-Secretion in Rabbit Colon." 1995.
R. M. Soll et al.; "N-Sulfonamides of Benzopyran-Related Potassium Channel Openers: Conversion of Glyburide Insensitive Smooth Muscle Relaxants to Potent Smooth Muscle Contractors", Bioorganic & Medicinal Chemistry Letters, vol. 4, No. 5, pp. 769-773, (1994).
Chemical Abstract vol. 123 No. 132796, Ecke et al, "A Chromanol Type of K+ Channel Blocker Inhibits Forskolin." 1995.
Brendel Joachim
Gerlach Uwe
Lang Hans Jochen
Weidmann Klaus
Covington Raymond
Hoechst Aktiengesellschaft
Kight John
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