Sulfonamide-substituted chromans, processes for their preparatio

Details Sulfonamide-substituted chromans, processes for their preparatio Sulfonamide-substituted chromans, processes for their preparatio

1998-09-25

1999-09-21

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

5142335, 514456, 540502, 544331, 544376, 544405, 5462827, 546196, 548159, 548214, 548245, 5482656, 5483051, 5483114, 5483644, 549404, A61K 3135, A61K 31535, C07D31168, C07D41312

Patent

active

059556072

ABSTRACT:
Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly efficacious substances for producing medicaments for the prophylaxis and for the therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal disorders.

REFERENCES:
patent: 4882353 (1989-11-01), Niewohner
Suessbrich, H. et al., "Specific blockade of slowly activating I.sub.sK channels by chromanols--impact on the role of I.sub.sK channels in epithelia", FEBS Letters 396 (1996), pp. 271-275.
Lohrmann, E. et al., "A new class of inhibitors of cAMP-mediated C1 secretion in rabbit colon, acting by the reduction of cAMP-activated K.sup.+ conductance", Pflugers Arch--Eur. J. Physiol. 429 (1995), pp. 517-530.

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