Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1980-08-22
1981-11-17
Waltz, Thomas A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
564 99, C07C14375, C07C14379
Patent
active
043013007
ABSTRACT:
There are disclosed compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n -- wherein n is 2 to 20, ##STR2## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy, and ##STR3## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n -- wherein n is 2 to 20, ##STR4## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy and racemates thereof.
There are also disclosed processes and intermediates utilized to produce the end products.
The end products have utility as agents exhibiting both .alpha. and selective .beta. adrenergic blocking action.
REFERENCES:
patent: 4010189 (1977-03-01), Smith
patent: 4041074 (1977-08-01), Main
patent: 4141987 (1979-02-01), Smith
patent: 4202978 (1980-05-01), Fahrenholtz et al.
Fahrenholtz Kenneth E.
Guthrie Robert W.
Kierstead Richard W.
Tilley Jefferson W.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Saxe Jon S.
Waltz Thomas A.
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