Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-10-05
2000-11-28
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
51425212, 51425412, 51425409, 51425403, 544359, 544392, 544393, A01N 4358, A61K 31495, C07D40300, C07D24104, C07D29500
Patent
active
061536121
ABSTRACT:
Sulfonamide compounds are described which are inhibitors of matrix metalloproteinases, particularly stromelysin-1 and gelatinase A (72 kD gelatinase). Also described are methods for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes using the compounds.
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Ortwine Daniel F.
Purchase, Jr. Claude F.
White Andrew D.
Ashbrook Charles W.
Raymond Richard L.
Schroeder Ben
Warner-Lambert & Company
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