Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-07-14
1999-11-02
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514345, 514350, 514311, 514312, 514351, 514376, 546153, 546169, 546300, 546335, 548228, 548229, 548556, 549 65, A01N 4342, C07D21520, C07D21512, C07D21414
Patent
active
059771372
ABSTRACT:
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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Bhisetti Govinda Rao
Murcko Mark A.
Tung Roger D.
Haley, Jr. James F.
Keating Dominic
Mangasarian Karen
Richter Johann
Vertex Pharmaceuticals Incorporated
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