Sulfonamide inhibitors of aspartyl protease

Details Sulfonamide inhibitors of aspartyl protease Sulfonamide inhibitors of aspartyl protease

1998-07-22

1999-12-21

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514524, 514311, 514376, 514464, 548169, 548550, 548228, 546169, 549475, 549448, A01N 4336, A61K 3140

Patent

active

06004957&

ABSTRACT:
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.

REFERENCES:
patent: 3743722 (1973-07-01), Nolan
patent: 4330542 (1982-05-01), Descamps et al.
patent: 4629724 (1986-12-01), Ryono et al.
patent: 5196438 (1993-03-01), Martin et al.
patent: 5354866 (1994-10-01), Kempf et al.

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