Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-05-23
1996-11-05
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544236, 544257, 544364, 544366, 544295, 544370, A61K 31495, C07D40302, C07D40314
Patent
active
055718116
ABSTRACT:
The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R.sup.1, R.sup.2 and R.sup.3 each independently are hydrogen or C.sub.1-4 alkyl; R.sup.4 and R.sup.5 each independently are hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R.sup.6 is C.sub.1-4 alkyl; or phenyl optionally substituted with halo, C.sub.1-4 alkylcarbonylamino, C.sub.1-4 alkyloxy, C.sub.1-4 alkyl or nitro; Z is C.dbd.O or CHOH; and ##STR2## is a radical of formula ##STR3## Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a method of treating Helicobacter infection.
REFERENCES:
patent: 4791111 (1988-12-01), Heeres et al.
patent: 4931444 (1990-06-01), Van Wauwe et al.
patent: 5254553 (1993-10-01), Heeres et al.
Heeres Jan
Mostmans Joseph H.
Stokbroekx Raymond A.
Van der Veken Louis J. E.
Janssen Pharmaceutica N.V.
Metz Charles J.
Myers, Jr. Richard S.
Shah Mukund J.
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