Sulfonamide derivatives as PPAR modulators

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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C514S443000, C548S467000, C549S051000, C549S052000, C549S054000, C549S055000

Reexamination Certificate

active

07655641

ABSTRACT:
The present invention is directed to a compound of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

REFERENCES:
patent: 5089514 (1992-02-01), Hulin
patent: 5232945 (1993-08-01), Hulin
patent: 5306726 (1994-04-01), Hulin
patent: 5902726 (1999-05-01), Kliewer et al.
patent: 5994554 (1999-11-01), Kliewer et al.
patent: 6248781 (2001-06-01), Jeppesen et al.
patent: 6306854 (2001-10-01), Brown et al.
patent: 6369098 (2002-04-01), Pershadsingh et al.
patent: 6506757 (2003-01-01), Tajima et al.
patent: 6518290 (2003-02-01), Sierra
patent: 7071220 (2006-07-01), Satoh et al.
patent: 0 930 229 (1999-07-01), None
patent: 1 167 357 (2002-02-01), None
patent: 1 216 980 (2002-06-01), None
patent: 2 359 082 (2001-08-01), None
patent: WO 97/28115 (1997-08-01), None
patent: WO 97/31907 (1997-09-01), None
patent: WO 01/00566 (2001-01-01), None
patent: WO 01/16120 (2001-03-01), None
patent: WO 02/16332 (2002-02-01), None
patent: WO 02/18355 (2002-03-01), None
patent: WO 02/100813 (2002-12-01), None
patent: WO 03/072099 (2003-09-01), None
Sato, et al., “Synthesis and evaluation of novel fluorinated sulotroban-related sulfonamide derivatives as thromboxane A2 receptor antagonists,”Eur. J. Med. Chem., 30, pp. 403-414 (1995).
Sato, et al., “Asymmetric Synthesis of the Sulfoxide Metabolite of On-579 By The Kagan Protocol,”Bioorganic and Medicinal Chemistry Letters, vol. 7 No. 19, pp. 2451-2454 (1997).
Shinozaki, et al., “Synthesis and thromboxane A2 antagonist activity of indane derivatives,”Bioorganic and Medicinal Chemistry Letters, vol. 9, pp. 401-406 (1999).
Sato, et al., “Synthesis and evaluation of novel sulfonamide derivatives as thromboxane A2 receptor antagonists I,”Eur. J. Med. Chem., vol. 29, pp. 185-190 (1994).
Berlot, et al., “Preparation of a dansylated fibrate, a new fluorescent tool to study peroxisome proliferation. Effect on hepatic-derived cell lines,”Biochimie, vol. 79, pp. 145-150 (1997).
Liu, et al., “Identification of a Series of PPARγ/δ Dual Agonists Via Solid-Phase Parallel Synthesis,”Bioorganic and Medicinal Chemistry Letters, vol. 11, pp. 2959-2962 (2001).
Sarges, et al., “Glucose Transport-Enhancing and Hypoglycemic Activity of 2-Methyl-2-phenoxy-3-phenylpropanoic Acids,” J. Med. Chem., vol. 39, No. 24, pp. 4783-4802 (Nov. 22, 1996).
Cobb, et al., “N-(2-Benzoylphenyl)-L-tyrosine PPAR Agonists. 3. Structure-Activity Relationship and Optimization of the N-Aryl Substituent,” J. Med. Chem., vol. 41, No. 25, pp. 5055-5069 (Dec. 3, 1998).
Bright, et al., “Competitive particle concentration fluorescence immunoassays for measuring anti-diabetic drug levels in mouse plasma,” Journal of Immunological Methods, vol. 207, No. 1, pp. 23-31 (Aug. 2, 1997).
Brooks, et al., “Design and Synehesis of 2-Methyl-2-{4-[2-(5-methyl-2-aryloxazol-4-yl)ethoxy]phenoxy}propionic Acids: A New Class of Dual PPAR Agonists,” J. Med. Chem., vol. 44, No. 13, pp. 2061-2064 (Jun. 21, 2001).
Shinkai, et al., “Isoxazolidine-3,5-dione and Noncyclic 1,3-Dicarbonyl Compounds as Hypoglycemic Agents,” J. Med. Chem., vol. 41, No. 11, pp. 1927-1933 (May 21, 1998).
Murugesan, et al., “Biphenylsulfonamide Endohelin Receptor Antagonists. 2. Discovery of 4′-Oxazolyl biphenylsulfonamides as a New Class of Potent, Highly Selective ETAAntagonists,” J. Med. Chem., vol. 43, No. 16, pp. 3111-3117 (Aug. 10, 2000).
Malamas, et al., “Azole Phenoxy Hydroxyureas as Selective and Orally Active Inhibitors of 5-Lipoxygenase,” J. Med. Chem., vol. 39, No. 1, pp. 237-245 (Jan. 5, 1996).
Meguro, et al., “Studies on Antidiabetic Agents. VIII. Synthesis and Hypoglycemic Activity of 4-Oxazoleacetic Acid Derivatives,” Chemical & Pharmaceutical Bulletin, vol. 34, No. 7, pp. 2840-2851 (1986).
Xu, Yanping, et al., “Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists,” J. Med. Chem, vol. 47, No. 10, pp. 2422-2425 (2004).

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