Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1989-05-26
1991-03-12
Lone, Werren B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514381, 514539, 514546, 514562, 514604, 548252, 548253, 560 12, 560145, 562 11, 562 15, 562 30, 562430, A61K 3118, C07C31119, C07C31714, C07D25704
Patent
active
049993453
ABSTRACT:
Sulfonamide derivatives of the formula I ##STR1## where R.sup.1 is a C.sub.1 -C.sub.4 -alkyl or phenyl group which may be substituted by halogen, trifluoromethyl or C.sub.1 -C.sub.4 -alkyl, R.sup.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl, A is a group CHOR.sup.3 C.dbd.O, C.dbd.S or C.dbd.N--OR.sup.4, R.sup.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl phenyl, benzyl or C.sub.1 -C.sub.4 -acyl, R.sup.4 is hydrogen or methyl, B may be methylene or ethylene in the m or p position or, of A is not carbonyl, may be methyleneoxy, the oxygen atom being bonded to the aromatic, and E is a carboxyl, phosphonic acid or sulfo radical, their physiologically acceptable salts, esters with C.sub.1 -C.sub.4 -alcohols or amides or the tetrazol-5-yl radical, their preparation and their use as drugs.
REFERENCES:
Journal Praktische Chemie, 77, 369-382 (1908).
Journal of the Pharmaceutical Society of Japan, 70, No. 5, 51-54, (1950).
Thrombosis Research 33, No. 3, 277-288, (1984).
Baldinger Verena
Lehmann Hand D.
Ruebsamen Klaus
Schmied Bernhard
BASF - Aktiengesellschaft
Clarke Vera C.
Lone Werren B.
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