Sulfonamide derivatives

Details Sulfonamide derivatives Sulfonamide derivatives

2002-06-07

2009-06-16

O'Sullivan, Peter G (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S394000, C514S466000, C514S471000, C514S569000, C514S603000, C546S338000, C548S309700, C549S451000, C549S495000, C562S427000, C564S082000, C564S086000

Reexamination Certificate

active

07547716

ABSTRACT:
A medicament for enhancing an effect of a cancer therapy based on a mode of action of DNA injury, which comprises as an active ingredient a compound represented by the general formula (I) or a physiologically acceptable salt thereof:wherein R represents an aryl-substituted alkyl group, an heteroaryl-substituted alkyl group, a cycloalkyl-substituted alkyl group, or a cyclic hydrocarbon group wherein said cyclic hydrocarbon group may be saturated, partly saturated, or aromatic; or Z may bind to R to form a cyclic structure, Z represents a hydrogen atom or a C1to C6alkyl group. The medicament enhanced the effect of the cancer therapy and decreases a dose of an anticancer agent and/or radiation, and therefore, can reduce side effects resulting from the cancer therapy.

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