Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-04-28
1996-04-09
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142315, 5142382, 514247, 514249, 514255, 514259, 514262, 514269, 514299, 514308, 514312, 514335, 514345, 514366, 514369, 514372, 514376, 514370, 514381, 514384, 514398, 514407, 514424, 514443, 514445, 514452, 514456, 514460, 514463, 514470, 514473, 514604, 544 59, 544106, 544228, 544239, 544253, 544257, 544265, 544298, 544315, 544316, 544319, 544384, 544408, 546138, 546153, 546242, 546243, 546293, 548183, 548213, 548228, 548251, 5482632, 5483071, 5483615, 548470, 548482, 548484, 548486, 549 14, 549399, 549
Patent
active
055062431
ABSTRACT:
Since sulfonamide derivatives of the present invention show strong inhibitory activity against cysteine protease such as calpain papain, cathepsin B, cathepsin H, cathepsin L, they can be used as remedies for muscular dystrophy, cataract, myocardial infarction, stroke, Alzheimer's disease, amyotrophia, osteoporosis, hypercalcemia or the like.
REFERENCES:
patent: 5081284 (1992-01-01), Higuchi
Sasaki et al., J. Enzyme Inhibition, 1990, vol. 3, No. 3, pp. 195-201.
Mehdi S. Cell-penetrating inhibitors of Calpain TIBS 16 Apr. 1991 pp. 150-153.
Ando Ryoichi
Fujimura Yoshiyuki
Sakaki Toshiro
Takahashi Chizuko
Huang Evelyn
Ivy C. Warren
Mitsubishi Kasei Corporation
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