Sulfonamide derivative and process for preparing the same

Details Sulfonamide derivative and process for preparing the same Sulfonamide derivative and process for preparing the same

1996-05-09

1998-04-14

Gupta, Yogendra N.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544123, 544298, 544319, 544323, 544324, 544325, 544327, 544331, 544332, C07D40312, C07D40314, C07D41312

Patent

active

057393338

ABSTRACT:
##STR1## wherein Ring A and Ring B are substituted or unsubstituted monocyclic, bicyclic or tricyclic hydrocarbon, or substituted or unsubstituted heterocyclic group, Q is single bond, --O--, --S--, --SO--, --SO.sub.2 -- or --CH.sub.2 --, Y is --0--, --S-- or --NH--, Alk is lower alkylene or alkenylene, Z is --O-- or --NH --, R is substituted or unsubstituted aromatic heterocyclic or aryl, R.sup.1 is H, substituted or unsubstituted amino, substituted or unsubstituted lower alkyl, alkenyl, alkynyl, substituted or unsubstituted lower alkylthio, or alkoxy, or substituted or unsubstituted heterocyclic or aryl, or pharmaceutically acceptable salts thereof, which are useful in the prophylaxis or treatment of disorders associated with endothelin activities such as hypertension, pulmonary hypertension, renal hypertension, Raynaud disease, bronchial asthma, gastric ulcer, chronic heart failure, etc.

REFERENCES:
patent: 3317536 (1967-05-01), Grussner
patent: 5270313 (1993-12-01), Burri et al.
patent: 5292740 (1994-03-01), Burri et al.
patent: 5589478 (1996-12-01), Yamada et al.
Chemical Abstracts, vol. 121, Abstract No. 230786g (1994).

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