Sulfonamide aminomethylene derivatives as immunosuppressants

Details Sulfonamide aminomethylene derivatives as immunosuppressants Sulfonamide aminomethylene derivatives as immunosuppressants

1995-09-26

1997-05-27

Wu, Shean C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514411, 514423, 548526, 548528, 548532, 548538, 548568, A61K 340, C07D20700, C07D40502

Patent

active

056332777

ABSTRACT:
Compounds which suppress human T-lymphocyte proliferation are disclosed. The active compounds essentially contain at least the following structure: ##STR1##

REFERENCES:
CA100(9):61785q (1983).
Poe et al., "Human Cytotoxic Lymphocyte Tryptase", The Journal of Biological Chemistry, 263(26):13215-13222 (1988).
Simon et al., "Purification and Characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes", The EMBO Journal, 5(12):3267-3274 (1986).

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